激素治疗无效的特发性血小板减少性紫癜的治疗方法分析

Hormone Therapy for Idiopathic Thrombocytopenic Purpura Curative Effect Observation

目的:研究激素治疗无效的特发性血小板减少性紫癜患者,运用脾切除术和免疫抑制剂治疗的临床效果。方法:我院选择2009年10月~2012年10月间运用激素治疗无效的104例特发性血小板减少性紫癜(ITP)的患者,根据治疗的方法不同将其分为两组,1组的40例患者运用脾切除术进行治疗,2组的64例患者运用免疫抑制剂方法进行治疗,比较两组患者的治疗效果。结果:通过对本文所选患者进行治疗,1组患者从治疗第3天开始到治疗24个月时BPC均比2组高,差异显著,有统计学意义(P<0.05);1组患者的有效率明显高于2组,差异显著,有统计学意义(P<0.05);1组患者经过治疗后出现不良反应的几率为15.0%,2组为45.0%。结论:对于激素依赖的或者激素治疗不敏感的ITP,运用脾切除治疗的临床效果好,患者出现的副作用少,而且短时间内即可见到效果,为首先的二线治疗方法。

Objective：To study the hormone refractory idiopathic thrombocytopenic purpura patients,clinical effect by splenectomy and immunosuppressive therapy.Methods：In our hospital from 2009 October^2012 year in October selected 104 cases of glucocorticoid refractory idiopathic thrombocytopenic purpura（ITP） patients,according to the different treatment methods can be divided into two groups,1 groups of 40 patients were treated by splenectomy,2 groups of 64 patients with immune inhibitor for treatment,compared two groups of patients.Results：The treatment of the selected by patients,1 patients in treatment for third days to 24 months treatment,BPC were lower than those in the 2 group,significant differences,with statistical significance（P〈0.05）;the 1 groups of patients with efficiency was higher in group 2,significant differences,with statistical significance（P〈0.05）;probability 1 groups of patients after treatment.The adverse reactions of 15%,2 group 45%.Conclusion：The hormone dependence or hormone therapy is not sensitive to the ITP,use the clinical effect of splenectomy for good,with less side effects,but a short period of time to see the effect,as second line therapy for the first.