老年糖尿病妇女骨质疏松的相关危险因素分析

Risk Factors Analysis of Osteoporosis in Old Women Patients with Type 2 Diabetes

目的:探讨绝经后2型糖尿病(type 2 diabetes mellitus,T2DM)合并骨质疏(osteoporosis,OP)女性患者骨密度的变化及其相关性。方法:绝经后2型糖尿病女性患被分为2组:T2DM组即T组(62例),T2DM合并骨质疏松组即P组(58例)。比较两组骨代谢、糖代谢等指标之间的差异,及进行相关分析。结果:P组年龄较大,绝经时间长,糖尿病病程长,BMI降低,FBG、HbA1C升高,差异有统计学意义(P<0.05);骨碱性磷酸酶(sBAP)、骨钙素(sOC)、Ⅰ型胶原交联C端肽(sCTx)和尿Ⅰ型胶原交联N端肽(uNTx)明显低于T组。相关性分析显示,患者BMD与糖尿病病程、年龄、HbA1C、FPG、FSH、LH、uNTx/Cr呈显著负相关。结论:绝经后T2DM合并骨质疏松与血糖控制不佳密切相关。

Study changes of bone density about postmenopausal women with type 2 diabetes mellitus （T2DM） and the correlation between osteoporosis （OP） and bone density.Methods：Postmenopausal women were divided into 2 groups： group T2DM,（group T, 62 cases）, group T2DM with osteoporosis （P group, 58 cases）. Comparison bone metabolism, glucose metabolism between two groups. Results：P group were older, postmenopausal long time, longer duration of diabetes, BMI lower, FBG, HbA1C increased, the difference was statistically signiifcant （P〈0.05）. Bone alkaline phosphatase （sBAP）, osteocalcin （sOC）, type I collagen cross-linked C end peptide （sCTx） and urinary type I collagen cross-linked N end peptide （uNTx） of group P was signiifcantly lower than group T. compared with T group, N group, serum FSH, LH of P group are increased, E2 is decreased （P〈0.05）. Correlation analysis showed that BMD is signiifcant negative correlation with and the duration of diabetes, age, HbA1C, FPG, FSH, LH, uNTx and /Cr, and no correlation with sBAP, sOC, sCTx.Conclusion：Osteoporosis of postmenopausal women with type 2 diabetes mellitus （T2DM） is related to poor glucose level.