山莨菪碱对ACS合并糖尿病肾病择期PCI术后肾功能保护作用的临床研究

Clinical Study on the Protective Effect on Renal Function in Patients with ACS Complicated with Diabetic Nephropathy Undergoing PCI by Anisodamine

目的:探究山莨菪碱对ACS合并糖尿病肾病患者接受择期PCI术后肾功能保护作用的临床效果。方法:选取2010年3月至2013年3月在我院接受治疗的180例ACS合并糖尿病肾病患者为研究对象,依循随机平均分配原则分为对照组和观察组,对照组术前静脉滴注使用氯化钠生理盐水,观察组术前静脉推注使用山莨菪碱药物,回顾性分析其术后疗效。结果:对照组PCI术后内生肌酐清除率与术前相比,具有显著差异,具有统计学意义(P<0.05)。且与观察组术后每个阶段内生肌酐清除率比较差异,具有统计学意义(P<0.05)。另外,对照组心率变化不大,观察组术前用药心率上升较快。结论:山莨菪碱对ACS合并糖尿病肾病患者接受择期PCI术后肾功能保护作用的临床效果较佳。

Objective：To explore the clinical effect of the protective effect of anisodamine on renal function in patients with acute coronary syndrome complicated with diabetic nephropathy undergoing elective PCI surgery.Methods：180 cases of patients with acute coronary diabetic nephropathy syndrome for the study in our hospital from March 2010 to March 2013, randomly assigned to follow the principles into control group and observation group, the control group patients using sodium chloride intravenous infusion of normal saline, before surgery, the observation group anisodamine intravenous drugs, retrospective analysis of the efifcacy of postoperative.Results：The control group after PCI endogenous creatinine clearance rate compared with the previous surgery, the difference was statistically signiifcant （P〈0.05）. And with the observation group after each stage of creatinine clearance rate difference, with statistical signiifcance （P〈0.05）. In addition, little change in heart rate in the control group, the observation group premedication before rising faster heart rate.Conclusion：The clinical effect of the protective effect of anisodamine on renal function in patients with acute coronary syndrome complicated with diabetic nephropathy undergoing elective had better clinical results.