复方甘草酸苷对抗结核药物所致药物性肝损害的治疗疗效分析

Effects Analysis on Compound Glycyrrhizin in Treatment of Liver Damage Induced by Antituberculosis Drugs

目的：探讨与分析复方甘草酸苷治疗抗结核药物所致的药物性肝损害的疗效。方法：对从2012年1月～2013年11月我院收治的病例中采集80例进行回顾性分析，依照患者自愿随机分组各40例，对照组给予肌苷以及还原型谷胱甘肽1.2克治疗，分析组给予复方甘草酸苷，对临床疗效进行观察与对比。结果：分析组有30例显效，9例有效，1例无效，总有效率为97.5%；对照组有20例显效，12例有效，8例无效，总有效率为80%，分析组显著高于对照组（P＜0.05）。结论：应用复方甘草酸苷能够治疗抗结核药物所致的药物性肝损害，效果显著，安全无毒副作用，可使肝损害的严重程度得到减轻。

Objective：To explore the therapeutic effect of compound glycyrrhizin in the treatment of drug-induced liver injury caused by anti TB drugs.Methods：From 2012 January～2013 year in November in our hospital were collected in 80 cases were analyzed retrospectively, in accordance with the voluntary patient randomly 40 cases, control group was given 1.2 grams of inosine and glutathione treatment, analysis group was given compound glycyrrhizin, were observed and compared the clinical efifcacy.Results：The analysis of group 30 cases were cured, 9 cases were effective, 1 cases ineffective, the total effective rate was 97.5%;the control group 20 cases were cured, 12 cases were effective, 8 cases ineffective, the total efifciency of 80%, analysis group was signiifcantly higher than that in control group （P〈0.05）.Conclusion：The application of compound glycyrrhizin in the treatment of drug-induced liver injury caused by anti TB drugs, the effect is remarkable, safe non-toxic side effects, the severity of liver damage can be mitigated.