摘要
目的：探讨联合检测临床常用的化验指标，BNP、TNI、CRP及D-二聚体在肺栓塞患者的诊断、病情判定及预后的指导意义。方法：前瞻性地收集2006年6月～2014年5月我院确诊的肺栓塞患者56例的临床资料，其中男32例，女24例，根据2011年美国肺栓塞诊治指南中有关诊断标准将患者分为三组：（1）大面积肺栓塞组（A组，8例）。（2）次大面积肺栓塞组（B组，28例）。（3）低危险性肺栓塞组（C组，20例）。其中死亡4例。记录患者入院时外周静脉血检测BNP、TNI、CRP及D-二聚体的结果。结果：（1）大面积肺栓塞组及次大面积肺栓塞组中的BNP、TNI、CRP水平均较低危险性肺栓塞组的水平明显升高，大面积肺栓塞组中的BNP、TNI及CRP的水平也高于次大面积肺栓塞组，各组之间相比有显著性差异，P＜0.05。三组中D-二聚体的水平均明显升高（与正常参考值相比较），但差异无明显统计学意义（P=0.3374）。（2）死亡患者的BNP、TNI、CRP水平明显高于非死亡患者，存在统计学差异，P＜0.05。两组间D-二聚体水平无明显统计学差异（P=0.2856）。结论：肺栓塞患者中，BNP、TNI及CRP水平越高，患者的危险分层越高，病情越重，死亡风险越高。对于可疑急性肺栓塞患者，常规检查D-二聚体可以有助于急性肺栓塞的早期诊断。
Objective： Acute Pulmonary Embolism is one of the common medical emergency,dangerous and with high incidence rate.This paper discusses the value of combined detection of BNP,TNI,CRP and D-dimer in diagnosis,and prognosis of the patients with Acute Pulmonary Embolism.Methods：We collected 56 patients which Acute Pulmonary Embolism were diagnosised,and divided into three groups：（1）Group of massive PE（Group A,8patients）.（2） Group of submassive PE（Group B,28patients）.（3）Group of low-risk PE （Group C,20patients）.4 patients in them were died.Records the levels of BNP,TNI,CRP and D-dimer when the patients arrived.Results：（1）The levels of BNP,TNI,CRP were much higher in group A and B than group C. The levels of BNP,TNI,CRP in group A were also much higher than group B（P〈0.05）.Three groups of D-dimer levels were signiifcantly higher （compared with normal reference values）,but the difference was not statistically signiifcant.（2）The levels of BNP,TNI,CRP in died patients were signiifcantly higher than those of patients who alived,there were signiifcant differences,no signiifcant difference between the two groups of D-dimer levels.Conclusion：Pulmonary embolism patients,who has higher BNP, TNI and CRP levels,the risk stratiifcation of patients is much higher,and with the higher risk of death.For patients with suspected acute pulmonary embolism,D-dimer examination can help in the early diagnosis.
出处
《中国医药导刊》
2014年第10期1290-1292,共3页
Chinese Journal of Medicinal Guide
