急性脑卒中后不同时期抑郁状况与认知功能障碍的相关性分析

Correlation Analysis of Depression at Different Times after Acute Stroke and Cognitive Dysfunction

目的:探讨脑卒中后不同时段抑郁状况与认知功能障碍的相关性分析。方法:选取急性脑卒中发病后72h、1个月、2个月及3个月HAMD评分≥8分且未接受抗抑郁药物治疗的患者纳入研究,分别于发病后72h及3个月两个时间段采用MoCA评分及P300认知电位检测评价脑卒中后抑郁(PSD)与认知功能障碍的关系。结果:各组发病后3个月时的MoCA评分均低于发病后72h的测量结果,且组间比较差异均有统计学意义(P<0.05);发病后72h,1个月组、2个月组及3个月组的MoCA评分均低于72h组的测量结果,且组间比较差异均有统计学意义(P<0.05);发病后3个月,1个月组、2个月组及3个月组的MoCA评分均低于72h组的测量结果,且组间比较差异均有统计学意义(P<0.05)。脑卒中急性发作后72h及3个月两个时间段,1个月组及2个月组潜伏期及波幅与72h组及3个月组比较差异均有统计学意义(P<0.05);脑卒中急性发作后3个月时,1个月组及2个月组的潜伏期均较脑卒中急性发作后72h时延长,且组间比较差异均有统计学意义(P<0.05)。结论:脑卒中急性发作后1个月及2个月时发生PSD可对认知功能产生更为严重的影响,应对PSD及认知功能进行及早筛查,并做好早期干预,以改善患者的预后。

Objective： To explore the correlation of depression at different times after acute stroke and cognitive dysfunction. Methods：Patients of different times after acute stroke of 72h,1 month,2 months and 3 months and whose HAMD score ≥8 points were chosed for the study.And the MoCA score and P300 of detection at 72h and 3monthes after stoke were determined to analyze the cognitive dysfunction.Results：There was statistically significant difference of the MoCA scores between the 3 months and 72 h after the strok（P〈0.05）.At 3 months after the strok, the MoCA scores of the groups of 72h,1 month group and 2 months group were lower than that of the 72h group（P〈0.05）.At 72h and 3 monthes after the strok,there was statistically significant difference of the latency and amplitude betweent the 1 month group,2 months group and 72h group,3 months group（P〈0.05）.At 3 monthes after the strok,the latency of the 1 month group and 2 months group were longer than those of 72h after the strok（P〈0.05）.Conclusion：The PSD happened at 1 month and 2 months after the strok could result the cognitive dysfunction,which showed us need early screen and make early intervention to improve the patient＆#39;s prognosis.