TEG评价AMI患者接受抗血小板治疗风险的研究

Study of Predictive value of TEG in Patients with AMI Receiving Antiplatelet Therapy

目的:探讨血栓弹力图(TEG)检测急性心肌梗死(AMI)经皮介入治疗(PCI)口服双联抗血小板药物患者对出血及心脏缺血事件的预测价值。方法:AMI冠脉PCI患者210例,接受阿司匹林和氯吡格雷双联抗血小板治疗,于术后第二天TEG检测二磷酸腺苷通道血凝块最大强度(MAADP)、二磷酸腺苷(ADP)和花生四烯酸(AA)诱导的血小板抑制率,随访1年观察出血事件及心脏缺血事件的相关性。结果:ADP、AA抑制率与心脏缺血事件明显相关;MAADP与出血事件相关。结论:TEG检测对预测AMI PCI接受双联抗血小板治疗的患者再发心脏缺血及出血事件有一定帮助。

Objective： To investigate the thromboelastography（TEG） for detection of acute myocardial infarction（AMI） percutaneous coronary intervention（PCI） oral double prediction of bleeding and cardiac ischemic events in patients with antiplatelet drug value. Methods： 210 cases of AMI patients with coronary PCI, received aspirin and clopidogrel dual antiplatelet therapy in second days after operation, TEG was detected in two amp channel clot maximum strength（MAADP）, adenosine monophosphate（ADP） two and four arachidonic acid（AA） induced platelet inhibition rate, the correlation of 1 years of follow-up observation of bleeding events and cardiac ischemic events. Results： ADP, AA inhibitory rate and cardiac ischemic events was significantly related to MAADP associated with bleeding events. Conclusion： Detection of TEG to predict AMI PCI received dual antiplatelet therapy in patients with recurrent cardiac ischemic and hemorrhagic events have some help.