内源乳化法制备2,4-D/海藻酸钠/羽毛蛋白微球及其缓释性能

Slow-release performance of 2,4-D / sodium alginate / feather protein microspheres prepared by emulsification / internal gelation and its slow release performance

以海藻酸钠(Sodium Alginate,SA)和羽毛蛋白(Feather Protein,FP)为载体材料,2,4-二氯苯氧乙酸(2,4-D)为模型药物,采用内源乳化法制备了2,4-D/SA/FP复合微球,并考察了羽毛蛋白与海藻酸钠的质量比、油水(体积)比、纳米碳酸钙用量对载药微球的形貌、载药性能和缓释性能的影响.结果表明,V(油)∶V(水)=3∶1,羽毛蛋白为海藻酸钠质量的30%,纳米碳酸钙用量为0.2 g时,所制得微球球形度较好,粒径分布较均匀,载药量为3.68%,具有良好的缓释性能.

2,4-D/sodium alginate/feather protein microspheres were prepared by emulsification/internal gelation method. The influence of the mass ratio of feather protein to sodium alginate, volume ratio of the oil to water, and the content of nano-calcium carbonate on the morphology, loading content and slow-release performance of the microspheres were studied. The results showed that the optimized conditions was ： the mass ratio of sodium alginate to feather protein was 100：30, the volume ratio of the oil to water was 3：1, the dosage of calcium carbonate was 0.2 g. Prepared with the optimized system the 2,4-D SA./ FP microspheres, had the loading content of 2,4-D was 3.68%, with uniform distribution and smooth surfaces with spherical geometry, and had a good slow release performance.