艾贝宁与米唑安定对ICU重症患者镇静镇痛效果比较

Clinical Effect Comparison between Dexmedetomidine Hydrochloride and Midazolam on Sedation and Analgesic Effect in ICU

目的:比较分析重症监护室(ICU)采用艾贝宁和米唑安定的镇痛与镇静作用的临床效果。方法:入选我院重症监护室符合标准的患者148例,按照用药的不同分为治疗组和对照组,每组74例;治疗组患者给予艾贝宁镇静与镇痛,对照组患者给予米唑安定镇静与镇痛,观察两组患者用药后的镇静情况和镇痛情况。结果:治疗组患者在ICU治疗的总时间、镇静维持的时间和机械通气的持续时间三方面显著优于对照组,结果差异具有统计学意义(P<0.05);治疗组患者用药后躁动的概率32.4%明显低于对照组74.3%,产生的不良反应18.9%显著低于对照组42.3%,结果具有显著性差异(P<0.01)。结论:重症监护室患者采用艾贝宁进行镇痛和镇静,有效的改善了临床的预后情况,缩短了机械通气的时间和ICU的滞留时间,减少了患者认知功能障碍的发生,临床疗效显著,值得推广。

Objective To explore the clinical effects of dexmedetomidine hydrochloride and midazolam on sedation and analgesic effect in ICU. Methods 148 patients in ICU conformed with criteria were chosen and divided into treatment group and control group each with 74 cases according to different medication methods. Treatment group was given dexmedetomidine hydrochloride and control group was given midazolam. Sedation and analgesic effect conditions of the 2 groups after medication were observed. Results For the total time, sedation sustaining time and mechanical ventilation lasting time in ICU, treatment group was obviously superior than control group （P 〈 0.05）; the occurrence rate of restlessness for treatment group was 32.4 %, which obviously lower than control group 74.3 %, occurrence rate of adverse reactions for treatment group was 18.9 % obviously lower than control group 42.3 % （P 〈 0.01）. Conclusion For ICU patients, dexmedetomidine hydrochloride has good sedation and analgesic effects. It can effectively improve clinical condition of prognosis, shorten mechanical ventilation time and ICU residence time, and reduce occurrence of cognition impairment of patients. It has an obvious clinical effect and is worth of being popularized.