HCY水平与脑梗死患者相关性的临床分析

Clinical analysis between homocysteine and severity in patients with cerebral infarction

目的探讨动脉粥样硬化型脑梗死患者急性期同型半胱氨酸的水平及其与病情严重程度的相关性。方法收集2011年2月-2012年5月入住我科的脑梗死患者,其中经TOAST分型后符合大动脉粥样硬化型(Ⅰ型)为研究组,对照组为同期健康体检者,两组均行Hcy水平检测,对脑梗死患者入院时采用美国国立卫生院神经功能缺损评分量表(NIHSS)及改良Rankin量表评分(MRS)进行评价,并对数据进行分析。结果与对照组相比,研究组Hcy水平明显升高,差异有统计学意义(P<0.05);而Hcy水平与脑梗死患者入院时NIHSS、MRS评分无统计学意义(P>0.05)。结论血浆Hcy水平增高可能是脑梗死的危险因素,脑梗死患者发病后Hcy水平不能反映病情严重程度。

[ Objective ] To explore the level of homocysteine and the relationship between homocysteine and severity in atheroselerotie patients with cerebral infarction. [ Methods ] Consecutive patients after cerebral infarction onset in the ward of Department of Neurology were analyzed from February 2011 to May 2012, then classified by TOAST, the TOAST- I patients were study group. Their homoeysteines at 24h after admission and healthy control group were measured. The study group patients were divided into four groups according to their homocysteine levels. [ Results ] Compared with healthy control group, the homoeysteine level of study group was higher（P〈0.05）. And the homoeysteine levels of the patients were not related with NIHSS and GCS scores at admission（P〉0.05）. [ Conclusion ] A high level of homoeysteine may be a risk factor for cerebral infarction, but homoeysteine level at admission eann＇t reflect severity of patients with cerebral infarction.