口服益生菌对高胆红素血症新生儿免疫功能的影响

Effect of oral probiotics on treatment of neonates with hyperbilirubinemia and its influence on immune function

目的探讨口服益生菌治疗新生儿高胆红素血症的疗效及其对免疫功能的影响。方法 167例高胆红素血症新生儿随机分为益生菌组87例和对照组80例。对照组采取常规蓝光疗法进行治疗,益生菌组采取光疗+口服益生菌类药物。比较半个月后2组新生儿体内血清总胆红素的含量和Ig M、CD4+、CD8+、CD4+/CD8+等免疫学指标。结果治疗后,益生菌组血清总胆红素的含量显著低于对照组(P<0.05),且益生菌组总血胆红素恢复至正常水平所需时间明显短于对照组(P<0.05)。益生菌组治疗总有效率为91.95%,显著高于对照组的62.5%(P=0.004)。益生菌组外周血液中CD4+/CD8+、Ig M水平显著优于对照组(P<0.05)。结论口服益生菌类药物治疗新生儿高胆红素血症疗效显著,可显著改善患儿的免疫功能。

Objective To explore the effect of oral probiotics on treatment of neonates with hyperbilirubinemia and its influence on immune function. Methods A total of 167 neonates with hyperbilirubinemia were randomly divided into probiotics group（ n = 87） and control group（ n = 80）.The control group was treated with conventional phototherapy,while the probiotics group was treated with phototherapy and oral probiotics. Content of serum total bilirubin as well as Ig M,CD4＋,CD8＋and CD4＋/ CD8＋were compared after half a month between two groups. Results After treatment,content of serum total bilirubin in the probiotics group was significantly lower than that in the control group（ P〈0. 05）,and time of serum total bilirubin covered to normal level was significantly shorter than that in the control group（ P〈0. 05）. The effective rate in the probiotics group was 91. 95%,which was significantly higher than the 62. 5% in the control group（ P = 0. 004）. Levels of CD4＋/CD8＋and Ig M in the peripheral blood in the probiotics group were significantly better than those in the control group（ P〈0. 05）. Conclusion Oral probiotics are effective in treating the neonates with hyperbilirubinemia,and it can significantly improve immune function of neonates.