hOGG1 Ser326Cys基因多态性与高频听力损失易感性关系的探讨

Investigation on relationship between hOGG1 Ser326Cys polymorphism and hearing loss susceptibility in high-frequency

目的探讨人8-羟基鸟嘌呤糖苷酶1（rs 1052133）的基因多态性（h OGG1 Ser326Cys）与高频听力损失易感性的关系。方法采用病例-对照的研究方法,根据《职业性噪声聋诊断标准》（GBZ49—2007）,病例组为电测听双耳高频平均听阈≥40 dB的工人,对照组为年龄和性别与病例匹配且电测听双耳高频平均听阈〈40 dB的同岗位轮班工人,基因型的测定采用Taqman探针法。结果通过分析发现h OGG1 Cys/Cys基因型可能是高频听力损失的危险因素（调整OR=2.82,95%CI=1.38-5.77）,分层分析发现h OGG1 Cys/Cys基因型与噪声作业工龄（〈15年）、噪声暴露水平[〈85 dB（A）]和吸烟等危险因素结合后,危险性可能增加（OR值变大）。结论 h OGG1 Cys/Cys基因型可能是汉族人群高频听力损失的危险因素之一。

Objective To investigate whether the h OGG1 Ser326 Cys polymorphism is associated with the susceptibility to high-frequency hearing loss in Chinese Han population. Methods A case-control method was used in this study,according to GBZ 49—2007,noise-exposed workers the binaural high frequency average hearing threshold not less than 40 dB were selected as observing cases,while those workers who worked in same workshop with the observing cases,had matched age,gender and the average hearing threshold was less than 40 dB in high frequency were selected as controls. Genotypes were measuredBy means of Taqman probe method. Results The study found that h OGG1 Cys / Cys genotype may be a risk factor of high-frequency hearing loss（ adjusted OR = 2. 82,95% CI = 1. 38—5. 77）,and the risk may become increased（ OR increased） when it combined with noise working years（ 〈15 years）, noise exposure levels [〈 85 dB（ A）〗, smoking and so on. Conclusion h OGG1 Cys / Cys genotype may be a risk factor of high-frequency hearing loss in Chinese Han population.