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中老年人肥胖与血清25(OH)D和胰岛素抵抗之间关系的研究 被引量：3

Association of adiposity with serum 25-Hydroxyvitamin D levels and insulin resistance in middle-aged and elderly people
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摘要 目的探讨中老年人肥胖与血清25(OH)D和胰岛素抵抗之间的关系。方法对健康查体的中老年人进行人体测量、实验室检查和问卷调查,根据体质指数(body mass index,BMI)和腰围(waist circumference,WC)对研究对象进行分层分析。结果与非肥胖组相比,肥胖组的收缩压(systolic blood pressure,SBP)、舒张压(diastolic blood pressure,DBP)、总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、空腹血糖(fasting plasma glucose,FPG)、空腹胰岛素(fasting insulin,FINS)、胰岛素抵抗指数(homeostasis model assessment of insulin resistance,HOMAIR)和代谢综合征患病率增高(均有P<0.001),血清25(OH)D降低(P<0.001)。BMI与25(OH)D呈负相关,WC与25(OH)D无明显相关;肥胖组的血清25(OH)D与空腹胰岛素和HOMA-IR呈负相关(均有P<0.05),但在体重正常和超重者中未见明显相关。腰围正常组和腹部肥胖组的血清25(OH)D与空腹胰岛素、HOMA-IR之间存在相关。结论 BMI分层比腹部肥胖分层分析25(OH)D与胰岛素抵抗之间的关系更具相关性。
作者 杨芳 张风芝 张蕾 刘永清
机构地区 聊城市疾病预防控制中心慢病科 聊城市人民医院营养科
出处 《中华疾病控制杂志》 CAS CSCD 北大核心 2015年第4期421-423,共3页 Chinese Journal of Disease Control & Prevention
关键词 胰岛素抵抗 肥胖症 中老年人
分类号 R589.25 [医药卫生—内分泌] R181.2 [医药卫生—流行病学]
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参考文献13

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二级参考文献24

  • 1廖岚,周智广.维生素D与自身免疫性糖尿病[J].国外医学（内分泌学分册）,2005,25(2):103-106. 被引量：5
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中华疾病控制杂志
2015年 第4期

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