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Hedgehog －Gli 信号通路在肺癌中的研究进展 被引量：2

Research progress of Hedgehog-Gli signaling pathway in lung cancer
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摘要 Hedgehog－Gli信号通路参与脊椎动物的胚胎发育、组织分化、器官形成，并且在稳定机体内环境、维持干细胞功能、调节上皮－间质转化中起重要作用。 Hedgehog－Gli信号通路的激活与多种肿瘤的发生发展、侵袭、凋亡及耐药密切相关。本文旨在阐明Hedgehog－Gli信号通路的组成，作用机制，在肺癌发生发展过程中的作用以及在EGFR－TKI治疗EGFR突变NSCLC耐药后的作用。 Hedgehog-Gli signaling pathway involves in vertebrate embryonic development ,tissue differ-entiation,organogenesis,and plays an important role in homeostasis ,the maintenance of stem cell function ,regula-tion of epithelial mesenchymal transition .Hedgehog-Gli signaling pathway activation correlates with a variety of tumor development ,invasion,apoptosis and drug resistance .This review seeks to clarify the composition of Hedge-hog-Gli signaling pathway ,mechanism of action ,the role of Hedgehog-Gli signaling pathway in lung cancer de-velopment and function of lung cell of the EGFR -TKI resistance .
作者 王磊(综述) 陈公琰(审校)
机构地区 哈尔滨医科大学附属肿瘤医院内一科
出处 《实用肿瘤学杂志》 CAS 2015年第2期178-182,共5页 Practical Oncology Journal
关键词 HEDGEHOG GLI 非小细胞肺癌 小细胞肺癌 EGFR-TKI耐药 Hedgehog Gli Non-small cell lung cancer Small cell lung cancer EGFR-TKI resistance
分类号 R734.2 [医药卫生—肿瘤]
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参考文献31

  • 1Chari NS, Mcdonnell TJ. The sonic hedgehog signaling net- work in development and neoplasia [ J 1. Adv Anat Pathol, 2007,14(5 ) :344 - 352.
  • 2Rajurkar M, De Jesus - Monge WE, Driseoll DR, et al. The activity of Gli transcription factors is essential for Kras - in- duced pancreatic tumorigenesis [ J ]. Proe Natl Acad Sei, 2012,109 (17) : 1038 - 1047.
  • 3Koso H, Tsuhako A, Lyons E, et al. Identification of FoxR2 as an oncogene in medulloblastoma [ J 1. Cancer Res, 2014, 74(8) :2351 -2361.
  • 4Sun L, Zhang C, Li P. Copolymerie micelles for delivery of EGCG and cyclopamine to pancreatic cancer cells [ J 1- Nutr Cancer,2014,66 ( 5 ) :896 - 903.
  • 5Wu G, Lu X, Wang Y, et al. Epigenetic high regulation of ATAD2 regulates the Hh pathway in human hepatocellular carcinoma[J]. Int J Oncol,2014,45( 1 ) :351 - 361.
  • 6Kang EJ, Jung H, Woo OH, et al. Association of aldehyde dehydrogenase 1 expression and biologically aggressive fea- tures in breast cancer [ J ]. Neoplasma, 2014,61 (3) : 352 - 362.
  • 7Beauchamp E, Bulut G, Abaan O, et al. GLI1 is a direct transcriptional target of EWS- FLI1 oncoprotein[ J]. J Biol Chem, 2009,284 ( 14 ) : 9074 - 9082.
  • 8Takanaga H,Tsuchida - Straeten N, Nishide K, et al. Gli2 is a novel regulator of sox2 expression in telencephalic neuro- epithelial cells [ J ]. Stem Cells,2009,27 ( 1 ) : 165 - 174.
  • 9Hui CC, Angers S. Gli proteins in development and disease [ J ]. Annu Rev Cell Dev Bio1,2011,27 (45) :513 - 537.
  • 10Wilson CW, Chuang PT. Mechanism and evolution of cy- tosolic Hedgehog signal transduction [ J ]. Development, 2010,137 ( 13 ) :2079 - 2094.

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实用肿瘤学杂志
2015年 第2期

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