九味羌活颗粒质量标准研究

Study on Quality Standard for Jiuwei Qianghuo Granules

目的：建立九味羌活颗粒质量标准。方法：采用TLC法对制剂中的川芎、苍术、甘草进行鉴别;用HPLC法测定黄芩苷的含量。结果：用薄层色谱法能较好的鉴别制剂中川芎、苍术、甘草。用HPLC法测定制剂中的黄芩苷,黄芩苷进样量在0.362~3.62μg之间与峰面积呈良好的线性关系（r=0.999 6）,平均回收率为100.52%,RSD为0.87%。结论：本法操作简便、结果准确,重现性好,可用于九味羌活颗粒的质量控制。

Objective To establish the quality standard for Jiuweiqianghuo Granules. Methods To discriminate Ligusticum Chuanxiong Holt. , Atractylodes lancea （Thunb.）DC. , Glycyrrhiza uraleusis Fish. with TLC and to determine the content of Baicalin by HPLC. Results TLC is effective for discrimination of Ligusticum Chuanxiong Hort. , Atraetylodes lancea （Thunb.） DC. ,Glycyrrhiza uraleusis Fish.. To determine the content of Baicalin in preparation by HPLC, the calibration cruve was linear within the concertration of 0. 362μg ~ 3.62μg（ r = 0.999 6 ）, the average recovery was 100.52% with RSD0. 87%. Conclusions The methods are simple, accurate, reproducible and suitable for the quality control of Jiuwciqianghuo Granules.