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TRPM8基因敲除小鼠的饲养繁殖及基因型鉴定

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摘要 瞬时型感受器电位蛋白（transient receptor potential，rrRP）是一种阳离子通道，它包括多个成员，哺乳动物中就存在三十多个，这些成员一般具有6个跨膜结构域，并以四聚体形式发挥作用。TRP离子通道受电压门控，而温度和配体则可通过改变电压而实现对通道开闭的调节，因此被认为是温度感知和温度调节的参与者。
作者 郅琳
机构地区 南阳理工学院张仲景国医学院综合教研室
出处 《中国药物与临床》 CAS 2015年第4期476-477,共2页 Chinese Remedies & Clinics
基金 高等学校博士学科点专项科研基金(20103107110008)
关键词 基因敲除小鼠 基因型鉴定 receptor 阳离子通道 温度调节 繁殖 饲养 电压门控
分类号 R562.25 [医药卫生—呼吸系统]
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参考文献5

  • 1段波,徐天乐.TRP通道与信号转导[J].生物物理学报,2005,21(4):245-260. 被引量：20
  • 2Cheung WY,Ha NR,Suen MW,et al. Warming up the cold re- ception at TRPM8 function[J]. Neurosci,2007,27:7616-7618.
  • 3Colsoul B, Niluius B, Vennekens R. On the putative role of tran- sient receptor potential cation channels in asthma[J]. Clin Exp Allergy, 2009,39 : 1456-1466.
  • 4Tsavaler L, Shapero MH, Morkowski S, et al. Trp-P8,a novel prostale-specifie gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient re- ceptor potential calcium channel proteins[J]. Cancer Res,2001, 61 : 3760-3769.
  • 5McKemy DD, Neuhansser WM,Julius D. Identification of a cold receptor reveals a general role for TRP channels in thermosensa- tion[J~. Nature, 2002,416: 52-58.

二级参考文献82

  • 1Zhu X, Jiang M, Peyton M, Boulay G, Hurst R, Stefani E,Birnbaumer L. trp, a novel mammalian gene family essential for agonist-activated capacitative Ca^2+ entry. Cell, 1996,85:661-671.
  • 2Moqrich A, Hwang SW, Earley TJ, Petrus MJ, Murray AN,Spencer KS, Andahazy M, Story GM, Patapoutian A .Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science, 2005,307:1468-1472.
  • 3Guler AD, Lee H, Iida T, Shimizu I, Tominaga M, Caterina M. Heat-evoked activation of the ion channel, TRPV4.J Neurosci, 2002,22:6408-6414.
  • 4Viana F, de la Pena E, Belmonte C. Specificity of cold thermotransduction is determined by differential ionic channel expression. Nat Neurosci, 2002,5:254-260.
  • 5Viswanath V, Story GM, Peier AM, Petrus MJ, Lee VM,Hwang SW, Patapoutian A, Jegla T. Opposite thermosensor in fruitfly and mouse. Nature, 2003,423:822-823.
  • 6Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J,Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D.Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science, 2000,288:306-313.
  • 7Ross RA. Anandamide and vanilloid TRPV1 receptors. Br J Pharmacol, 2003,140:790-801.
  • 8Corey DP, Garcia-Anoveros J, Holt JR, Kwan KY, Lin SY,Vollrath MA, Amalfitano A, Cheung EL, Derfler BH, Duggan A, Geleoc GS, Gray PA, Hoffrnan NIP, Rehm HL,Tamasauskas D, Zhang DS. TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells.Nature, 2004,432:723-730.
  • 9Nagata K, Duggan A, Kumar G, Garcia-Anoveros J. Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing. J Neurosci, 2005,25:4052-4061.
  • 10Zhang y, Hoon MA, Chandrashekar J, Mueller KL, Cook B,Wu D, Zuker CS, Ryba NJ. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell, 2003,112:293-301.

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中国药物与临床
2015年 第4期

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