颅内转移癌不同治疗方案的比较研究

A Comparative Study of Intracranial Metastases of Different Treatment Options

目的:探讨颅内转移癌的不同治疗方案及其疗效。方法:回顾分析124例颅内转移癌住院患者的临床资料,124例患者分别选择单纯外科手术治疗(A组),外科手术配合术后全脑放射治疗(WBRT,B组)以及立体定向分次放射治疗(FSRT)配合WBRT(C组)。评估三种治疗方案在颅内转移癌神经外科治疗中的优劣。结果:B组对A组治疗颅内转移癌在上述三方面均具有显著统计学差异(P<0.05);特定条件下C组对A组治疗颅内转移癌在上述三方面也具有明显统计学差异(P<0.05)。结论:对于新发,直径大于3cm,周边水肿,占位效应明显的颅内转移癌病灶手术切除,术后WBRT效果好;对直径不超过3cm的单发颅内转移癌病灶,占位效应轻微或不明显,可以行FSRT辅助WBRT。

Objective： To explore Discussion of intracranial metastases and efficacy of different treatment options.Methods：Retrospective analysis of 124 cases of hospitalized patients with intracranial metastases, 124 patients were selected surgical treatment alone （A group）, surgery with postoperative whole brain radiation therapy （WBRT, group B） and FSRT with WBRT （group C）. Assess the pros and cons of three treatment regimens in the treatment of brain metastases in neurosurgery. Results：Group B to Group A treatment of intracranial metastases in the above three areas were signiifcant statistical difference（P〈0.05）;under certain conditions set C for the treatment of intracranial metastases in group A in the above three areas also have signiifcant difference（P〈0.05）. Conclusions：For new development, diameter greater than 3cm, peripheral edema, intracranial mass effect evident metastatic lesion resection, postoperative WBRT good effect;less than 3cm in diameter solitary brain metastasis cancer lesions, minor or no mass effect obviously, you can line FSRT auxiliary WBRT.