高血压合并非酒精性脂肪性肝病与胰岛素抵抗及同型半胱氨酸相关性的探讨

Research of Nonalcoholic Fatty Liver Disease with Homocysteine and Insulin Resistance in Patients with Essential Hypertension

目的:研究高血压合并非酒精性脂肪性肝病(NAFLD)与胰岛素抵抗(IR)、同型半胱氨酸(Hcy)的关系及相关影响因素。方法:原发性高血压患者200例分为2组:(1)高血压合并NAFLD组(A组)102例。(2)单纯高血压组(B组)98例。测量身高、体重、血压、血脂、肝酶、血糖、Hcy等指标,计算体重指数(BMI)、IR指数(HOMA指数),两组进行比较。结果:A组BMI、收缩压(SBP)、甘油三酯(TG)、空腹胰岛素(FINS)、空腹血糖(FBG)、HOMA指数、Hcy较B组明显升高(P<0.05),logistic回归分析显示BMI、FINS、TG、FBG、Hcy是A组主要危险因素。结论:IR、血脂代谢紊乱、高Hcy血症增加高血压合并NAFLD的患病风险。

Objective： To investigate the association of nonalcoholic fatty liver disease（NAFLD）with insulin resistance（IR） and homocysteine（Hcy） in patients with essential hypertension, and to analyze the risk factors.Methods：A total of 200 patients with hypertension including 102 with NAFLD and 98 without NAFLD were recruited.Height,weight,blood pressure, blood lipids,liver enzymes,fasting blood glucose（FBG）, Hcy and HbA1c levels were detected.Body mass index（BMI）, IR index（HOMA index） were calculated and compared between two groups.Results：Compared with non-NAFLD group, BMI, triglyceride（TG）, HOMA index were signiifcantly higher in NAFLD group（P〈0.05）, Logistic regression analysis showed that BMI,TG,FINS,FBG,IR index,Hcy were independent factors.Conclusion：IR, lipid disorders and Hcy were signiifcantly associated with increased risk of NAFLD in in patients with essential hypertension.