羟基喜树碱膀胱灌注联合热疗对浅表性膀胱癌术后复发的影响研究

Effects research of HCPT bladder perfusion combined hyperthermia on preventing recurrence postoperative of superficial bladder cancer

目的研究羟基喜树碱(HCPT)膀胱灌注联合热疗对浅表性膀胱癌术后复发的影响。方法选择114例浅表性膀胱癌行经尿道膀胱肿瘤电切术患者为研究对象,采用随机数字表法分为观察组和对照组各57例,对照组单纯采用羟基喜树碱膀胱内灌注化疗,观察组采用羟基喜树碱膀胱内灌注联合体外热疗。比较两组复发情况及远期生存率。结果观察组6个月、1年、1.5年、2年复发率均明显低于对照组(3.51%vs 19.30%,10.53%vs24.56%,14.04%vs 29.82%,14.04%vs 35.09%);2年生存率明显高于对照组(87.72%vs 73.68%)。结论羟基喜树碱膀胱灌注联合热疗能有效降低浅表性膀胱癌术后复发率,提高远期生存率。

Objective To study the effect of HCPT bladder perfusion combined hyperthermia on preventing recurrence postoperative of superficial bladder cancer. Methods 114 cases superficial bladder cancer with transurethral bladder tumor resection were divided into observation group and control group,control group given HCPT bladder perfusion chemotherapy, observation group given HCPT bladder perfusion combined hyperthermia. Relapse and long-term survival rate were com-pared. Results Recurrence rates of observation group 6 months,1 year,1. 5 year,2 years were significantly lower than that control group（3. 51% vs 19. 30%,10. 53% vs 24. 56%,14. 04% vs 29. 82%,14. 04% vs 35. 09%）;2 year survival rate were significantly higher than that control group（87. 72% vs 73. 68%）. Conclusion HCPT bladder perfusion combined hyperthermia therapy can reduce superficial bladder cancer postoperative recurrence rate,improve long-term survival rate.