泉州地区女性人乳头状瘤病毒基因型与宫颈病变的关系

Relationship between human papillomavirus genetypes and cervical lesions of women in Quanzhou

目的探讨泉州地区女性人乳头状瘤病毒(HPV)基因型的感染率,及各基因型与宫颈疾病的关系。方法采用导流杂交基因芯片法对泉州地区5 080例女性进行HPV分型检测,同时,对1 154例进行临床病理组织诊断。结果筛查人群中HPV的总感染率为24.37%(1 238/5 080),感染率最高为HPV16型,占总感染数的24.72%(306/1 238)。各年龄段HPV的感染率差异有统计学意义(χ2HPV=13.801,P<0.01)。HPV16在宫颈病理组织中感染率逐级增高(χ2趋势=214.356,P<0.01)。结论 HPV基因型感染与宫颈病变的发生密切相关,其中HPV16、HPV18感染易致宫颈病变进展乃至癌变发生,检测HPV基因型是筛查和监测宫颈病变的有效辅助方法 。

Objective To explore the infection rate of human papilloma virus（HPV）genotypes and the relationship between genotypes and cervical lesions of women in Quanzhou.Methods A total of 5 080 women were collected by liquid-based method for 21 subtypes of HPV by flow through hybridization and gene chip technology,which1 154 cases by clinical pathology diagnosis.Results The positive rate of HPV in 5 080 women was 24.37%.HPV16 was the most common type,which is accounted 24.72%in infected women.There was significant difference in HPV positive rates among the investigated age group（χ2HPV=13.801,P〈0.01）.HPV16 infection rates increased progressively in the grade of histopathological diagnoses（χ2trend=214.356,P〈0.01）.Conclusion HPV genotypes infection is related to the cervical lesions.Among them,HPV16,HPV18 infection is the primary cause of cervical disease progression and carcinogenesis.HPV detection is a valuable technique for screening and monitoring of secondary cervical lesions.