261株鲍曼不动杆菌临床分布及耐药性分析

Clinic distribution and drug resistance of 261 strains of Acinetobacter baumannii

目的对本院2012年8月至2014年7月检出的261株鲍曼不动杆菌进行耐药性分析,为临床治疗鲍曼不动杆菌感染提供依据。方法按常规方法进行细菌培养,检测本院2012年8月至2014年7月间送检的各种临床标本(包括痰液、脓液、分泌物、尿液、血液和引流液等),应用VITEK-2 Compact全自动微生物分析系统对临床分离的病原菌进行鉴定和药敏试验,利用WHONT 5.6软件分析鲍曼不动杆菌的耐药性及其分布。结果共检出261株鲍曼不动杆菌,其中多重耐药菌141株(54.0%),83株多重耐药鲍曼不动杆菌分离自ICU和呼吸科。结论鲍曼不动杆菌多重耐药情况很严重,尤其是分离自ICU和呼吸科的标本,实验室应加强鲍曼不动杆菌耐药检测,临床医师应根据细菌的药物敏感性试验结果合理选用抗生素,同时应加强医院感染监测,做好隔离,防止医源性传播。

Objective To investigate the resistance status of 261 strains of Acinetobacter baumannii detected in our hospital from August 2012 to July 2014, and provide basis for the clinical treatment of Acinetobacter baumannii infection. Methods Iso- lated bacteria were separated from kinds of clinical specimen including sputum, pus, secretions, urine, blood and purulent fluid of patients from August 2012 to July 2014. They were cultured by routine methods, also identified and performed drug susceptibility testing by automatic analysis system VITEK 2 compact. The drug resistance and its distribution of Acinetobacter baumannii were conducted by WHONET 5.6 software. Results A total of 261 stains of Acinetobacter baumannii were isolated, among them, there were 141 stains of multidrug resistant （54.0%） were identified, with 83 strains of multidrug resistant Acinetobacter baumannii were identified from ICU and respiratory department. Conclusion The drug resistance of Acinetobacter baumannii was serious, especially the specimen separaed from ICU and respiratory department. It is essential to strengthen testing for the drug resistant of Acinetobacter baumannii, and to reasonably use antibiontics according to the bacterial drug sensitivity testing results by clinicians, as well as monitoring hospital infection, and isolating patients to perventiatrogenic transmission.