摘要重症监护病房（ICU）危重患者应激性高血糖,同时伴有与应激相关的胰岛素抵抗,在过去的研究中曾认为中度的血糖升高是可以接受的现象[1]。Van den Berghe等[2]先后临床研究得出结论：对危重患者进行强化胰岛素治疗（通过适应胰岛素静脉持续泵入方式控制血糖于4.4--6.1mmol/L可以明显降低危重患者临床相关并发症的发生率和临床病死率。
1McCowen KC, Malhotra A, Bistrian BR. Stress-induced hyperglycemia. Crit Care Clin, 2001, 17:107
2Scott JF, Robinson GM, French JM, et al. Glucose potassium insulin infusions in the treatment of acute stroke patients with mild to moderate hyperglycemia: the glucose insulin in stroke trial (GIST).Stroke,1999,30:793
3Malmberg K.Prospective randomized study of intensive insulin treatment on long term survival after acute myocardial infarction in patiens with diabetes mellitus. BMJ, 1997,314:1512
4Greet Van Den Berghe,Pieter Wouters,Frank Weekers,et al. Intensive insulin therapy in critically ill patients.N Engl J Med,2001,345:1359
