固有淋巴细胞的发育与功能

The development and function of innate lymphoid cells

固有淋巴细胞(innate lymphoid cells,ILC)是一种新近发现的具有获得性免疫功能的免疫细胞,它作为辅助性T细胞的"镜像细胞"而受到广泛关注。根据分泌细胞因子的不同,ILC被分为三个亚群,这些亚群在不同组织的免疫反应中分别发挥重要作用,并与疾病起始和进程相关。就ILC的命名分类、不同亚群的功能和相关疾病以及其发育分化过程分别进行综述。

The newly identified innate lymphoid cells （ILCs） are a member of innate lymphocytes which can function as adaptive T cell. As the ＂mirror image＂ of T helper cell, they are of high concern recently. ILCs are divided into 3 subsets based on the secretion of distinct cytokines. These subgroups play important role in the immune responses of different tissues respectively, and they are associated with several diseases. Here, we review the classification of ILCs, the development and differentiation of ILCs, the functions of their distinct subgroups, and also their relationship with diseases.