病毒非经典途径合成蛋白质的分子机制

The molecular mechanism of viral protein synthesis by non-canonical pathway

病毒增殖过程涉及到病毒与宿主蛋白之间复杂的相互作用。为充分利用病毒基因组的有限资源,使病毒基因组编码的蛋白质数量最大化,除经典途径之外,病毒还可通过非经典途径来合成蛋白质。现就非经典途径中,对病毒蛋白质合成的起始、延伸以及终止过程的类型及特征进行综述,为深入研究病毒蛋白质合成的分子机制及抗病毒分子靶标的开发提供参考。

The complicated interactions between viral proteins and host proteins are involved in the process of viral propagation. To facilitate viral infection and propagation, the compact nature of viral genome has resulted in the evolution of specialized strategies to maximize their coding capacity. This review will highlight recent progresses of the non-canonical translation including the initiation, elongation and termination steps of viral protein synthesis in non-canonical translation, which will provide deep insights into facilitating further research of viral protein synthesis and the development of new target for clinical treatment.