吲哚-2，3双加氧酶（IDO）调节免疫的最新进展被引量：2

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摘要吲哚胺2,3-双加氧酶（IDO）是一种含血红素限速酶，其催化色氨酸转化为犬尿氨酸，而犬尿氨酸是色氨酸主要代谢产物。IDO已经在非肝细胞中被发现，主要表达于滋养层细胞，树突细胞，单核细胞和巨噬细胞。IDO的表达与T细胞的免疫调节相关，其主要通过降解外周细胞中的色氨酸发挥调节作用。色氨酸是一种必需氨基酸，是所有生命合成蛋白的一种重要原料并参与其它重要的代谢功能。本文将对IDO的免疫调节的机制最新进展做一综述。

作者贺继刚严丹王平李洪荣

机构地区云南省第一人民医院

出处《浙江临床医学》 2015年第4期647-649,共3页 Zhejiang Clinical Medical Journal

基金国家自然科学基金（81460073）

关键词 3-双加氧酶调节免疫 IDO 吲哚胺犬尿氨酸免疫调节滋养层细胞必需氨基酸

分类号 R338.12 [医药卫生—人体生理学]

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