孕妇血清维生素D水平的表达及意义

Expression and significance of serum vitamin D levels in pregnant women

目的探讨在不同季节、城乡之间孕妇血清维生素D含量的差异。方法选取2013年6月—2013年8月(夏季)和2013年12月—2014年2月(冬季)我院妇产科收治的正常怀孕中期孕妇分别为夏季组和冬季组,采用高效液相色谱-串联质谱法检测并比较两组孕妇血清25-(OH)D水平,并分别将两组按照城乡居住环境再分组,比较其血清25-(OH)D水平。结果夏季组25-(OH)D水平高于冬季组,差异有统计学意义(P<0.05),冬季组维生素D缺乏程度较夏季组严重,差异有统计学意义(P<0.01),夏季组中城市孕妇的25-(OH)D水平低于农村孕妇,差异有统计学意义(P<0.05),冬季组中城市孕妇的25-(OH)D水平与农村孕妇比较,差异无统计学意义(P>0.05)。结论孕妇维生素D水平存在明显的季节差异和城乡差异,冬季孕妇的维生素D水平较缺乏,夏季城市孕妇维生素D较缺乏。

Objective To investigate the difference of seasonal,urban and rural areas of Vitamin D nutritional status in pregnant women.Methods Normal pregnant women in our hospital from 2013 June to 2013 August（summer）and from 2013 December to 2014 February （winter）were selected as summer 25-（OH）D levels group and winter group re-spectively,detecting and comparing the 25-（OH）D levels of two groups were underwent using high performance liquid chromatography tandem mass spectrometry,and compared with the serum 25-（OH）D levels between the urban and ru-ral living environment in every group.Results 25-（OH）D levels in summer group was higher than that in winter group,the difference was statistically significant （P 〈0.05）,deficiency degree of vitamin D in winter group was worse than that in summer group,the difference was statistically significant （P 〈0.01）,25-（OH）D levels of urban pregnant women in summer group was lower than that in rural pregnant women,the difference was statistically significant（P 〈0.05）,there was no statistically significant differences about 25-（OH）D levels between urban and rural pregnant women in winter group（P 〉0.05）.Conclusion There have obvious difference about Vitamin D levels in seasonal,urban and rural areas in pregnant women,Vitamin D levels in pregnant women is shortage,Vitamin D levels in pregnant women of urban in summer is deficient.