舒血宁治疗Ⅳ～Ⅴ期糖尿病肾病的临床研究

Clinical study on the treatment with Sbuxuening for diabetic nephropathy in Ⅳ-Ⅴ stage

目的 观察舒血宁治疗Ⅳ~Ⅴ期糖尿病肾病（DN）的疗效。方法 将50例DN患者随机分为2组,对照组25例给予常规治疗,在此基础上治疗组25例给予舒血宁注射液20mL静脉点滴,1次/d,持续静滴2周。观察2组治疗前后血糖、血脂、肝肾功能、24 h尿蛋白定量及微量白蛋白系列、血清视黄醇结合蛋白变化情况。结果 2周后治疗组24 h尿白蛋白定量、尿微量白蛋白定量、血肌酐、尿素氮、血清视黄醇结合蛋白水平均明显下降,肾小球滤过率明显上升,同治疗前及对照组比较差异均有统计学意义（P均〈0.05）。结论 舒血宁治疗Ⅳ~Ⅴ期糖尿病肾病疗效好,可明显改善肾功能。

Objective It is to observe the curative effect of Shuxuening on diabetic nephropathy （DN） in Ⅳ~Ⅴ stage. Methods 50 patients with DN were randomly divided into 2 groups, 25 cases in the control group were given conventional treatment, 25 cases in the treatment group were treated with Shuxuening 20mL by intravenous drip once per day for two weeks on the basis of treatment in the control group. The changes of blood glucose, lipid, hepatic and renal function, 24 hour urinary protein, albumin series, serum retinol binding protein before and after treatment in both groups were observed. Results After 2 weeks＇ treatment, 24h urinary albumin, serum creatinine, blood urea nitrogen, serum retinol binding protein decreased sig- nificantly, while GFR increased significantly in the treatment group, compared with that before treatment and in the control group, the differences were all statistically significant（P 〈 0.05）. Conclusion Shuxuening has a significant curative effect on the advanced diabetic nephropathy inⅣ~Ⅴstage, and can obviously improve the renal function.