2011年至2014年鲍曼不动杆菌的分离结果及耐药性分析

In 2011～2014 Acinetobacter Baumannii Separation Results and Drug Resistance Analysis

目的了解鲍曼不动杆菌（AB）、耐亚胺培南鲍曼不动杆菌（IRAB）的病区分布、标本来源及耐药性，指导临床合理用药。方法回顾性分析2011年至2014年分离的AB和IRAB的标本来源、病区分布特点；对比分析其耐药性。结果AB和IRAB的主要标本来源均为痰液，构成比分别为81．0％（748／923）和82．9％（595／718）；主要病区来源均为重症监护病房（ICU），构成比分别为47．0％（434／923）和57．8％（415／718）。IRAB的检出率为77．8％（718／923）。IRAB除对阿米卡星耐药率为28．1％，复方新诺明为53．5％外，对其他11种抗菌药物耐药率高达92．5％～100．0％。非耐亚胺培南鲍曼不动杆菌（ISAB）的抗菌活性较好，对哌拉西林／他唑巴坦、阿米卡星的耐药率为2．9％～7．3％；IRAB对大多数抗菌药物的耐药率明显高于ISAB，差异有统计学意义（P〈0．05）。结论IRAB的耐药率较高；医院应做好本院细菌耐药监测结果，加强控制ICU等重点病区IRAB的感染和传播。

Objective Understanding of acinetobacter baumannii （AB）, resistant to imine culture south ward of acinetobacter baumannii （IRAB） distribution, specimen source and resistance, to guide clinical rational drug use. Methods From 2011 to 2014 were retrospectively analyzed separation of AB and IRAB source of spec-imen, ward distribution characteristic;Analysis of its resistance. Results AB and IRAB＇ s main source of spu- tum specimens, the constituent ratio was 81.0% （748/923） and 82.9% （595/718）;Major source of ward are intensive care unit （ICU）, and the constituent ratio was 47.0 % （434/923） and 57.8 % （415/718）. IRAB de- tection rate was 77.8% （718/923）. IRAB in addition to amikacin resistant rate to 28.1%, compound new north Ming was 53.5 %, the other 11 kinds of antimicrobial resistant rate is as high as 92.5 % -100.0%. Not resistant to imine culture south acinetobacter baumannii （ISAB） has good antibacterial activity, of piperacillin/ he tempie, amikacin resistant rate of 2.9 % - 2.9 % ; IRAB for most of the antimicrobial agents, significantly higher percentages of ISAB, difference was statistically significant （P 〈 0.05 ）. Conclusion IRAB higher prevalence of resistance; Hospital should do well in our hospital bacterial drug resistance monitoring results, strengthen the control of ICU ward key IRAB infection and spread.