生物组织光声成像技术综述

Photoacoustic Imaging:A Powerful Tool for Capturing Chemical Information in Tissue

光声成像是一种低功率、非电离的成像方式,既具有声学方法对深层组织成像分辨率高的优点,又具有光学方法在功能成像、分子成像方面具有高对比度的优势。本文回顾了近年来,光声成像技术在生物医学领域的研究进展,介绍了光声成像的基本成像原理。以此为基础,本文介绍了光声成像的两种主要成像方案:光声断层成像和光声显微镜,并且讨论了光声成像在获取生物组织化学成分信息和微结构信息方面的优越性;最后,本文对光声成像技术的优点和应用前景进行了总结。

Photoacoustic imaging（PAI）is a state of art biomedicine imaging technique in the 21 st century,for it inherits the high resolution of ultrasonography in deep tissue and the ability of optical imaging in biochemical information detection simultaneously.The recent progresses of PAI in biomedicine are reviewed.The basic principles and two major implementations of PAI,photoacoustic tomography and photoacoustic microscopy are introduced.Then the capability of multi-wavelength PAI in evaluating chemical components in tissues,and the feasibility of PA spectral analyses in evaluating histological microstructures in biological tissue are demonstrated,at the same time,several analysis methods and clinical applications of PAI in biomedical imaging are discussed.Finally,the advantages and potential applications of PAI in biology and medicine are sunmarized.