齐拉西酮与利培酮治疗流浪精神分裂症患者靶症状的对照研究

A Comparative Study between Ziprasidone and Risperidone on the Treatment of Target Symptoms for Vagrant Mental Patients with Schizophrenia

目的:探究齐拉西酮与利培酮对流浪精神分裂症靶症状治疗的临床疗效、不良反应之间的差异。方法:选择100例符合入组标准的流浪精神分裂症患者,并将这些患者随机分为齐拉西酮组和利培酮组,每组各50例,8周为一个疗程。用阳性与阴性症状量表(PANSS)、治疗中出现的症状量表(TESS)以及临床总体印象量表(CGI)评定不良反应和临床疗效。结果:一个疗程后,齐拉西酮组有效率和显效率分别为86.5%和64.6%,利培酮组分别为86.5%和68.5%,两组疗效相当(P>0.05);一个疗程后,就PANSS评分而言,两组较开始时均明显减低,两组差异在统计学上未达到显著程度,但齐拉西酮对阴性症状的改善优于利培酮组;齐拉西酮组不良反应总发生率显著低于利培酮组,齐拉西酮组几乎未引起锥体外系反应、月经改变、体重增加等不良反应。结论:齐拉西酮和利培酮都对治疗流浪精神分裂症靶症状疗效显著且相当。齐拉西酮的不良反应比利培酮更少,尤其在阴性症状的改善方面疗效显著,对长期的流浪有阴性症状严重的精神分裂症患者在临床应用方面具有重要价值。

Objective：To Investigate the differences between ziprasidone and risperidone upon adverse reaction and clinical effect on the target symptoms of vagrant schizophrenia.Methods：100cases of patients who met the criteria for vagrant schizophrenia were selected and randomly divide them into ziprasidone group and risperidone group,50 cases for each group,each course of treatment lasted for 8weeks.Evaluate and determine adverse reaction and clinical effect based on PANSS,TESS and CGI.Results：After one course of treatment,the effective rate and significant rate of ziprasidone group were 86.5% and 64.6% respective,which was 86.5%and 68.5%respective in risperidone group,the clinical effect in the two groups were nearly same,in terms of PANSS score,compared with that before treatment,it had declined in both group,the differences between the two groups were not statistically significant,but the improvement in negative syndromes made by ziprasidone was superior to that made by risperidone.The overall occurrence rate of adverse reaction in ziprasidone group was lower than that in risperidone group,there was nearly no occurrence of extrapyramidal disorder,menstrual changes,weight gain and other adverse reaction.Conclusion：Both ziprasidone and risperidone were effective to target symptoms of vagrant schizophrenia and their effect was comparative.The adverse reaction of ziprasidone is less than that of risperidone,and it is especially effective in improving negative syndromes,it is of clinically great value for treating those severe vagrant mental patients with schizophrenia complicated with long term of negative syndromes.