全氟化合物前体物质生物转化与毒性研究进展

Perfluorinated compound precursors: Biotransformation and toxicity

全氟化合物前体物质在环境和人体中广泛分布,是全氟化合物污染的重要间接来源.由于这些前体物质可以转化为具有生物富集性、多器官毒性,并且半衰期更长的全氟磺酸(PFSAs)和全氟烷酸(PFCAs),近年来受到了越来越多的关注.此外,一些全氟化合物前体物质自身或者代谢中间体也具有一定的生物学毒性,如类激素作用、蛋白偶联、细胞毒性等等,这些都可能造成人群暴露的潜在健康危害.本篇综述针对于全氟烷酸和全氟磺酸类的前体物质,总结了该类化合物在环境分布、生物转化和相关毒性研究方面的最新进展.

Perfluoroalkyl and polyfluoroalkyl substances （ PFASs ） precursors, as one potential indirect source of PFASs contamination, have been detected in environmental and human samples worldwide. Due to their metabolic transformation to perfluorosulfonic acids （ PFSAs ） and perfluorocarboxylic acids （ PFCAs） with longer elimination half-lives, higher bioaccumulation and multiple organ toxicities, these compounds have attracted more and more attention in recent years. Apart from transformation into PFASs, some of these precursors themselves or their metabolic intermediates also have toxicity effects, such as estrogen-like properties, protein binding, cytotoxicity and so on, and there might be a potential harmful impact on human health. In this review, the environmental release, biotransformation and toxicity of PFSAs and PFCAs precursors were summarized.