四瓣崖摩化学成分研究

Chemical Constituents from Amoora tetrapetala

从楝科崖摩属植物四瓣崖摩的树枝中分离得到14个化合物,运用波谱学方法分别鉴定为:22ξ-hydroxytirucalla-7,24-dien-3,23-dione(1)、dymacrin D(2)、泽屋萜(3)、α-菠菜甾醇(4)、8-hydroxy-6-methoxy-3-pentylisocoumarin(5)、ichenxanthone(6)、10-oxo-isodauc-3-en-15-al(7)、(+)-ent-ficusol(8)、3-甲氧基-4-羟基苯甲酸甲酯(9)、香草醛(10)、2,4-二羟基-3,6-二甲基苯甲酸甲酯(11)、2-羟基-4-甲氧基-6-丙基苯甲酸甲酯(12)、2,4-二羟基-6-甲基苯甲酸甲酯(13)和琥珀酸甲酯(14),以上化合物均为首次从崖摩属植物中分离得到。采用Elman比色法对全部化合物进行活性测试,结果表明化合物11对乙酰胆碱酯酶具有抑制活性。

Fourteen compounds were isolated from the branches of Amoora tetrapetala and structurally identified by spectral analysis. The compounds were identified as 22^-hydroxytirucalla-7,24-dien-3,23-dlone （1）, dymacrin D （2）, zeorin （ 3 ）, a-spinasterol （ 4 ）, 8 -hydroxy-6-methoxy-3-pentylisocoumarin （ 5 ）, lichenxanthone （ 6 ）, 10-oxo-isodauc-3-en-15-al （ 7）, （ ＋ ） -ent-ficusol （ 8 ）, 3 -methoxy-4-hydroxybenzoate （ 9 ）, vanillln （ 10 ）, methyl 2,4-hydroxy-3,6 -dimethylbenzo- ate （11）, methyl 2-hydroxy-4-methoxy-6-propylbenzoate （12）, methyl 2,4-dihydroxy-6-methylbenzoate （13） and methyl hydrogen sucoinate （14）. All the compounds were isolated from this genus for the first time. All eheraical constituents were tested for aeetylcholinesterase inhibitory activity using the Ellman colorinetric method. The results indicated that compound 11 exhibited inhibitory activity against acetylcholinesterase.