国产无线动力胶囊对健康受试者全消化道动力评估试验

Investigation of whole gut transit with domestic wireless motility capsule in healthy subjects

目的评估应用国产无线动力胶囊健康受试者的胃肠p H、压力、温度、局部和全消化道传输时间。方法 2014年6-8月我院招募的8例无症状健康受试者早餐（标准试餐热量为1 083 k J）后吞服胶囊,于腰间佩戴数据接收器,实时记录胃肠p H、压力、温度,然后根据这些数据计算胃排空时间（gastric emptying time,GET）、小肠传输时间（small bowel transit time,SBTT）、结肠传输时间（colon transit time,CTT）和全消化道传输时间（whole gut transit time,WGTT）。结果胃、小肠和结肠p H分别为0.7-2.9（2.0±0.82）,7.0-8.6（8.0±0.56）和5.9-7.6（6.8±0.61）。胃、小肠和结肠压力波峰值分别为18.0-31.8（24.8±4.84）mm Hg（1 mm Hg=0.133 k Pa）,33.7-60.5（42.4±10.75）mm Hg和42.6-74.2（55.6±10.44）mm Hg。胃、小肠和结肠温度分别为36.5-38.1（37.1±0.59）℃,36.5-37.6（37.0±0.41）℃和36.6-37.5（37.1±0.33）℃。GET为0.7-4.4 h,平均2.6 h;SBTT为3.4-6.3 h,平均5.4 h;CTT为10.5-15.9 h,平均12.6 h;WGTT为16.4-24.2 h,平均20.6 h。结论无线动力胶囊是一种评估消化道p H、压力、温度和传输时间的新技术,其具有无创、无放射性、便携的特点,临床上可用于评估动力性和功能性胃肠病。

Objective To assess gastrointestinal pH, pressure, temperature, regional and whole gut transit times with the domestic wireless motility capsule in healthy subjects.Methods Eight healthy asymptomatic subjects who were recruited from June to August 2014 in our hospital swallowed the domestic wireless motility capsule （WMC） after a standardized breakfast （1 083 kJ）. A data receiver was put on each subject＆-39;s abdomen and the synchronous transmission of pH, pressure and temperature data were recorded. Then gastric emptying time （GET）, small bowel transit time （SBTT）, colon transit time （CTT） and whole gut transit time （WGTT） were calculated according to the recorded data.ResultsGastric, small bowel, and colon pH values ranged from 0.7 to 2.9 （2.0±0.82）, 7.0 to 8.6 （8.0±0.56）, 5.9 to 7.6 （6.8±0.61）, respectively. Gastric, small bowel and colon peak contraction amplitude ranged from 18.0 to 31.8 （24.8±4.84） mmHg （1 mmHg=0.133 kPa）, 33.7 to 60.5 （42.4±10.75） mmHg, 42.6 to 74.2 （55.6±10.44） mmHg, respectively. Gastric, small bowel and colon temperature ranged from 36.5 to 38.1 （37.1±0.59）℃, 36.5 to 37.6 （37.0±0.41）℃, 36.6 to 37.5 （37.1±0.33）℃, respectively. GET ranged from 0.7 to 4.4 [2.6 （mean）] h, SBTT ranged from 3.4 to 6.3 [5.4（mean）] h, CTT ranged from 10.5 to 15.9 [12.6（mean）] h, WGTT ranged from 16.4 to 24.2 [20.6（mean）] h.Conclusion The WMC is a novel ambulatory technology offering a noninvasive and nonradioactive method to assess gastrointestinal pH, pressure and temperature, allowing for the measurement of whole gut transit times, which should be considered as an effective method by gastroenterologists to evaluate the alimentary motility and functional GI disorders.