疏肝健脾针刺法治疗抑郁障碍的临床随机对照研究

Clinical Observation on Acupuncture of Strengthening Spleen and Soothing Liver Method on Patients with Major Depressive Disorder

目的:观察疏肝健脾针刺法治疗抑郁障碍的临床疗效。方法:将105例患者随机分为3组,疏肝健脾针刺组、非经非穴组和西药组,各35例。3组均治疗8周,观察3组临床疗效,并依据汉密尔顿抑郁量表(HAMD-17)评分及生活质量综合评定量表(GQOLI-74)对治疗效果及生活质量进行评定。结果:(1)入组8周时,疏肝健脾针刺组总有效率为90.00%、非经非穴组为64.29%、西药组为90.91%,疏肝健脾针刺组和西药组优于非经非穴组(P<0.05);治疗后3个月,疏肝健脾针刺组总有效率为93.33%、非经非穴组为71.43%、西药组为87.88%,疏肝健脾针刺组优于非经非穴组和西药组(P<0.05)。(2)入组8周时,疏肝健脾针刺组与西药组相比,HAMD-17减分率与GQOLI-74总分没有显著差异(P>0.05)。(3)治疗后1个月、治疗后3个月时,疏肝健脾针刺组与西药组相比,HAMD-17减分幅度与GQOLI-74总分相比有显著性差异(P<0.01)。结论:疏肝健脾针刺可以显著改善抑郁障碍患者的HAMD-17与GQOLI-74评分,近期疗效与西药相当,但远期疗效优于西药治疗。其疗效的持续可能与针刺对机体的整体调整有关。

Objective：To observe the acupuncture of strengthening spleen and soothing liver method on patients with major depressive disorder（MDD）.Methods：Totally 105 cases of MDD were randomized into three groups：observation group（acupuncture of strengthening spleen and soothing liver method,n = 35）,non-acupoints group（n = 35） and medicine group（n = 35）.Three groups were treated for 8 weeks and then we observed the clinical curative effect.The therapeutic effect was evaluated with the Hamilton Rating Scale for Depession-17 items（HAMD-17） and the Generic Quality of Life Inventory-74（GQOLI-74）.Results：（1） The total effective rates of the observation group,non-acupoints group and medicine group were 90.00%,64.29%and 90.91% after 8 weeks＇ treatment respectively and the total effective rates of the observation group and western medicine group were superior to that of the non-acupoints group（P〈0.05）.The total effective rates of the observation group,non-acupoints group and medicine group were 93.33%,71.43% and 87.88% 3 months after treatment and the total effective rate of the observation group was superior to that of the non-acupoints group and medicine group（P〈0.05）.（2） There were no significant differences between the observation group and western medicine group on the scores of HAMD-17 and GQOLI-74 after treatment（P〉0.05）.（3） There were significant differences between the observation group and medicine group in the scores of HAMD-17 and GQOLI-74 1 and 3 months after treatment（P〈0.01）.Conclusion：The acupuncture of strengthening spleen and soothing liver method can obviously improve the scores of HAMD-17 and GQOLI-74.Its recent curative effect is the same as that of the western medicine,but the long-term curative effect is superior to that of western medicine with more persistence.