血清总胆汁酸的检测在妊娠期肝内胆汁淤积症中的临床价值

Clinical value of determination of total bile acid in intrahepatic cholestasis of pregnancy

目的探讨血清总胆汁酸(TBA)水平对妊娠期肝内胆汁淤积症(ICP)的诊断价值。方法对48例ICP患者(ICP组)和48例健康孕妇(对照组)用Beckman LX 20全自动生化仪上进行总胆汁酸(TBA)、总胆红素(TBIL)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)的检测。结果 ICP组与健康对照组比较,可看出ICP组TBA值明显升高,差异具有统计学意义(P<0.01);同时TBIL、ALT、AST与对照组比较,差异也具有统计学意义(P<0.01);且随着孕期延长,ICP患者TBA水平有增高趋势。结论 TBA是检测胆汁淤积较敏感指标,可作为孕产妇筛查ICP患者常规检测项目。

Objective To discuss the clinical value of determination of total bile acid（TBA） in the diagnosis of intrahepatic cholestasis of pregnancy（ICP）. Methods Forty-eight patients with ICP（ICP group） and 48 healthy pregnant women（control group） were received the determination of the total bile acid（TBA）,total bilirubin（TBIL）,alanine amino-transferase（ALT） and aspartate aminotransferase（AST） by Beckman LX20 automatic chemical analyzer.Results Compared with the control group, TBA value was significantly higher in ICP group, with the statistical difference（P〈0.01）;meanwhile,values of TBIL,ALT and AST were also significantly higher in ICP group compared with the control one,with the statistical difference（P〈0.01）;besides,with the extension of pregnancy,patients with ICP tended to have higher level of TBA. Conclusion TBA is a relatively sensitive indicator to detect the intrahepatic cholestasis and it can be used as one of routine inspection items for pregnant women to screen patients with ICP.