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单克隆抗体治疗免疫疾病的研究进展 被引量:2

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摘要 单克隆抗体是继疫苗和重组蛋白后最重要的一类生物制剂,已成功应用于治疗自身免疫性疾病和肿瘤等疾病中。单抗药物经历了从鼠源单抗、嵌合单抗到人源单抗和全人源单抗的发展过程。随着人源化单抗应用比例的提高,药物不良反应的发生率不断降低,治疗效果和安全性逐步提高,因此全人源单抗是单抗发展的趋势。本文阐述了四种有代表性的全人源单抗在免疫系统疾病治疗中的作用机制和临床评价。
作者 于雪 季强
机构地区 天津市儿童医院
出处 《天津药学》 2015年第2期70-72,共3页 Tianjin Pharmacy
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