摘要
目的:通过对急性心肌梗死(AMI)得到成功再灌注治疗患者细胞因子和心肌酶水平的观察,探讨此时心功能变化与细胞因子的关系及黄芪的调节和治疗意义。方法:将接受溶栓治疗的AMI患者随机分为黄芪组和对照组,依据再通标准进行判断,根据再通与否再次分组:未再通亦未应用黄芪30例为未通组(I组);再通未应用黄芪31例为再通组(R组);再通亦应用黄芪33例为黄芪组(T组)。分别检测肿瘤坏死因子(TNF)、干扰素(IFNγ)和白细胞介素-6(IL-6),观察再灌注时心肌酶和心功能的变化。结果:R组 TNF、IL-6和IFNγ比I组在2h和4h后明显增高,而T组有所恢复。结论:本研究发现AMI再灌注后2h即出现TNF、IL—6和IFNγ升高,梗死面积缩小,心功能得到改善。黄芪对再灌注后细胞因子的变化有一定的抑制作用,心功能得到进一步改善。
Objective: To observe the changes of cardiac function and cytokines in AMI patients treated with throm-bolysis and the effects of Astragalus Membrane.Methods: AMI patients treated with thrombolysis were randomly divided into Astragalus Membranceus and control groups. All patients weredivided into group I, group R, and group T according to reperfusion standard. The cardiac function was observed, and TNF, IL - 6, and IFN γ were measured. Results: The cardiac function in group R was better than that in group I, but lower than that in group T. Conclusion: TNF, IL - 6, and IFNγ elevated, the area of infarction decreased, and the cardiac function improved after reperfusion in AMI patients. Cardiac function in patients treated with Astragalus Mebranceus improved.
出处
《天津医药》
CAS
北大核心
2002年第8期454-456,共3页
Tianjin Medical Journal
基金
天津市卫生局科学基金资助(98KYGG-8)
关键词
细胞因子
急性心肌梗塞
再灌注损伤
黄芪
心肌酶
myocardial infarction acute disease reperfusion injury astragalus membranaceus