黄芪对心肌缺血-再灌注时细胞因子变化的影响

Effects of Astragalus Membranceus on Changes of Cytokines during Myocardia Ischemia Reperfusion

目的:通过对急性心肌梗死（AMI）得到成功再灌注治疗患者细胞因子和心肌酶水平的观察,探讨此时心功能变化与细胞因子的关系及黄芪的调节和治疗意义。方法:将接受溶栓治疗的AMI患者随机分为黄芪组和对照组,依据再通标准进行判断,根据再通与否再次分组:未再通亦未应用黄芪30例为未通组（I组）;再通未应用黄芪31例为再通组（R组）;再通亦应用黄芪33例为黄芪组（T组）。分别检测肿瘤坏死因子（TNF）、干扰素（IFNγ）和白细胞介素-6（IL-6）,观察再灌注时心肌酶和心功能的变化。结果:R组 TNF、IL-6和IFNγ比I组在2h和4h后明显增高,而T组有所恢复。结论:本研究发现AMI再灌注后2h即出现TNF、IL—6和IFNγ升高,梗死面积缩小,心功能得到改善。黄芪对再灌注后细胞因子的变化有一定的抑制作用,心功能得到进一步改善。

Objective: To observe the changes of cardiac function and cytokines in AMI patients treated with throm-bolysis and the effects of Astragalus Membrane.Methods: AMI patients treated with thrombolysis were randomly divided into Astragalus Membranceus and control groups. All patients weredivided into group I, group R, and group T according to reperfusion standard. The cardiac function was observed, and TNF, IL - 6, and IFN γ were measured. Results: The cardiac function in group R was better than that in group I, but lower than that in group T. Conclusion: TNF, IL - 6, and IFNγ elevated, the area of infarction decreased, and the cardiac function improved after reperfusion in AMI patients. Cardiac function in patients treated with Astragalus Mebranceus improved.