T-SPOT.TB在肺结核合并糖尿病患者诊断中的价值

Diagnostic value of T-SPOT.TB in patients with diabetes combined with pulmonary tuberculosis

目的探讨结核杆菌T细胞斑点实验(T-SPOT.TB)对肺结核合并糖尿病患者的诊断价值。方法以临床诊断为金标准,比较T-SPOT.TB、抗酸杆菌涂片法、TB-DNA法及结核菌素皮试(TST)检测41例肺结核合并糖尿病的诊断灵敏度。结果在对41例临床确诊为肺结核合并糖尿病患者中,T-SPOT.TB诊断灵敏度(95.12%)显著高于抗酸杆菌涂片(31.70%)、TB-DNA(43.90%)及TST(68.29%)(P<0.05)。T-SPOT.TB对菌阳肺结核确诊率(95.45%)与菌阴肺结核确诊率(94.74%)比较差异无统计学意义(P>0.05)。结论 T-SPOT.TB诊断肺结核合并糖尿病具有良好的灵敏度,且对其诊断与鉴别具有重要临床价值。

Objective To evaluate the diagnostic value of T-SPOT. TB in patients with diabetes combined with pulmonary tuberculosis. Methods With the clinical diagnosis as the gold standard, the sensitivities of T-SPOT. TB, acid fast bacilli smear method, TB-DNA and tuberculin skin test（TST）to diabetes combined with pulmonary tubereulogis were eompared. Results In 41 patients confirmed with diabetes combined with pulmonary tuberculosis, the diagnostic sensitivity of T-SPOT. TB （95.12%）was significantly higher than those of acid fast bacilli smear method（31.70% ） ,TB-DNA（43.90% ）and TST（68.29% ） （P 〈 0.05 ）. There was no statistical differ- ence in T-SPOT. TB diagnosis sensitivity to sputum smear-positive tuberculosis （95.45%） and smear-negative tuberculosis （94.74%） （P 〉 0. 05）. Conclusion T-SPOT. TB assay has satisfactory sensitivity to diagnose pulmonary tuberculosis combined with diabetes and has an important clinical value in the diagnosis of pulmonary tuberculosis combined with diabetes.