期刊文献+

败血症患者调节性T细胞与CD64指数的相关性分析

下载PDF
导出
摘要 目的:检测败血症患者血CD4+CD25+调节性T细胞(CD4+CD25+Treg)和CD64指数,探讨二者的相关性。方法:采用流式细胞仪检测败血症组及对照组的血CD4+CD25+Treg和CD64指数,同时测定白细胞数(WBC)和C-反应蛋白(CRP)的水平,并进行比较、分析。结果:(1)CD4+CD25+Treg、CD64、WBC、CRP败血症组明显高于对照组;死亡组患者明显高于生存组,差异均有统计学意义(P<0.05);(2)生存组和对照组CD4+CD25+Treg、CD64两项指标不同时间变化不明显;(3)CD64指数与CD4+CD25+Treg呈正相关关系,有统计学意义(P<0.05)。结论:连续、动态观察败血症患者的CD4+CD25+Treg与CD64指数,有助于正确评估其发展方向和预后,为早期合理使用药物提供支持。
作者 汪月强
出处 《中国高等医学教育》 2015年第3期129-129,136,共2页 China Higher Medical Education
  • 相关文献

参考文献2

二级参考文献36

  • 1杨宗城.烧伤治疗学[M].3版,北京:人民卫生出版社,2006:111-112.
  • 2Nishikawa H, Sakaguchi S. Regulatory T cells in tumor immunity[J]. Int J Cancer, 2010,127(4) : 759-767.
  • 3Sakaguchi S, Miyara M, Costantino CM, et al. FOXP3^+ regulatory T cells in the human immune system[J]. Nat Rev Immunoi,2010,10(7) :490-500,.
  • 4Sakaguchi S,Sakaguchi N, Asano M, et al. Pillars article: immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor ( alpha }-chains (CD25). Break down of a single mechanism of self-tolerance causes vari ous autoimmune diseases[J]. J Immunol, 2011,186 (7) 3808-3821.
  • 5Vernal R,Garcia-Sanz JA. Th17 and Treg cells, two new lymphocyte subpopulations with a key role in the immune response against in{ection[J]. Infect Disord Drug Tar- gets, 2008,8 (4) : 207-220,.
  • 6Huang LF, Yao YM, Dong N, et al. Association between regulatory T cell activity and sepsis and outcome of se- verely burned patients: a prospective, observational study [J]. Crit Care, 2010,14 (1) : R3.
  • 7Sakaguchi S, Wing K, Miyara M. Regulatory T cells-a Brief history and perspective[J]. Eur J Immunol, 2007.37 (Suppl 1) :Sl16-123.
  • 8Sakaguchi S. Regulatory T cells: history and perspective[J]. Methods Mol Biol,2011,707(8) :3-17.
  • 9Mendoza L,Pardo F. A robust model to describe the dif- ferentiation of T-helper eells[J]. Theory Biosci, 2010,129 (4):283-293.
  • 10Fontenot JD, Rasmussen JP, Gavin MA, et al. A function for interleukin 2 in Foxp3-expressing regulatory T cells [J]. Nat Immunol,2005,6(11) :1142-1151.

共引文献40

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部