多西他赛联合奥沙利铂与替加氟方案治疗晚期胃癌疗效观察

Docetaxel Plus Oxaliplatin and Tegafur Regimen in the Treatment of Patients with Advanced Gas-tric Cancer

【目的】观察多西他赛联合奥沙利铂与替加氟方案治疗晚期胃癌的临床疗效和不良反应。【方法】32例均经病理组织学诊断为胃癌，初治病例18例，复治病例14例，每例均完成至少2个周期化疗。治疗方案：多西他赛75 mg／m2，d1，静滴2 h；奥沙利铂130 mg／m2，d2，静滴；替加氟800 mg／m2，微量泵持续静滴，维持22 h ，d2～3，21 d为一周期。【结果】32例患者总有效率为17例（53．1％），中位肿瘤进展时间（T T P ）13个月，不良反应为白细胞下降24例（75．0％），恶心，呕吐21例（65．6％），周围神经毒性13例（40．6％），脱发10例（31．3％）。【结论】多西他赛联合奥沙利铂与替加氟方案治疗晚期胃癌临床疗效好，不良反应可耐受。

[Objective] To explore the efficacy and toxicity of docetaxel plus oxaliplatin and tegafur in the treatment of patients with advanced gastric cancer .[Methods] A total of 32 patients with advanced gastric cancer diagnosed pathologically were enrolled .The chemotherapy regimen consisted of docetaxel （75 mg/m2 ,day 1） ,ox‐aplatin （130 mg/m2 ,day 2） and tegafur （800 mg/m2 ,day 2~3） every 3 weeks .All patients completed at least 2 cycles of chemotherapy .[Results] Among them ,17 patients （53 .1% ） showed complete （ n =1） and partial （ n=16） responses .The median time to progression was 13 month .The major toxicities included myelosppression , vomiting ,neurotoxicity and alopeeia . And the incidence of hypolekocytosis was 75 .0% , nausea ＆amp; vomiting 65 .6% ,neurotoxicity40 .6% and alopecia 31 .3% .[Conclusion] Docetaxel plus oxaliplatin and tegafue is effica‐cious and well‐tolerated in the treatment of advanced gastric cancer .