血浆同型半胱氨酸与冠状动脉病变程度的相关性研究

Correlation Between Homocysteine Level and the Severity of Coronary Artery Lesions

【目的】探讨血浆同型半胱氨酸（Hcy）与冠状动脉病变程度的相关性。【方法】检测2014年1～7月在湖南省人民医院行冠脉造影的126例患者血浆 Hcy水平，利用Gensini评分系统对患者的冠脉病变程度进行评估。根据造影结果设为冠心病（CHD）组（90例），包括稳定型心绞痛（SAP）组（40例）及非ST段抬高型急性冠脉综合征（NSET‐ACS ）组（50例），另设为正常对照组（36例）；根据 Hcy水平＞10μmol／L ，设为高同型半胱氨酸（HHcy）组（94例）及同型半胱氨酸正常（非HHcy）组（32例）；利用直线相关分析，探讨 Hcy水平与Gensini评分的相关性。【结果】 CHD组的 Hcy水平明显高于对照组（ P ＜0．01），Hcy水平随Gensini评分升高而升高，两者呈正相关。H Hcy组的Gensini评分显著高于非 H Hcy组（ P ＜0．01 ），三支及双支病变组Hcy水平显著高于单支病变组（ P ＜0．01）。【结论】血浆 Hcy水平与冠状动脉病变程度呈正相关。

[Objective] To explore the relationship between the plasma level of homocysteine （Hcy） and the se‐verity of coronary artery lesions .[Methods] The plasma levels of Hcy were measured in 126 patients receiving coro‐nary angiography examination at our hospital from January 2014 to July 2014 .The severity of coronary artery was e‐valuated with the Gensini system .And their correlation was analyzed .Based upon the results of coronary angiography examination ,they were divided into control （ n=36） and coronary heart disease （CHD ,n=90） groups .The CHD group included stable angina pectoris （SAP ,n=40） and non‐ST segment elevation acute coronary syndrome （NSET‐ACS ,n=56） .According to the levels of Hcy〉 10μmol/L ,they were divided into high Hcy （HHcy ,n=94） and normal Hcy （ n=32） groups .And the data were statistically analyzed with statistical software SPSS 19 .0 .[Re‐sults] Plasma level of Hcy was much higher in CHD group than that in control group （ P〈0 .01） .And the Gensini score of HHcy patients was higher than that of Hcy normal counterparts （ P〈0 .01） .Plasma levels of Hcy of three/double‐vessel groups were higher than those of single‐vessel group （ P〈0 .01） .And plasma level of Hcy and Gensini score were positively correlated .[Conclusion]Plasma level of Hcy is associated with the degree of coronary artery le‐sions .