毛蚶提取物对环磷酰胺增效减毒作用的研究

Synergism and Attenuation Effects of Scapharca Subcrenata Extraction on Cyclophosphamide

研究毛蚶提取物对环磷酰胺的增效和减毒作用。采用腹水型S180小鼠和免疫低下小鼠模型为实验对象,以其抑瘤率、白细胞、巨细胞吞噬功能、溶血素水平和胸腺、脾脏指数为指标,评价毛蚶提取物对环磷酰胺的增效减毒作用。毛蚶提取物(100、200、400 mg·kg-1,i.g)与环磷酰胺合用比单用环磷酰胺抑瘤率明显提高,明显抑制环磷酰胺引起的白细胞下降,提高了免疫低下小鼠单核吞噬细胞的吞噬功能,提高了小鼠溶血素水平和免疫器官指数。毛蚶提取物通过免疫调节作用对环磷酰胺有明显的增效减毒作用。

To investigate the synergism and attenuation effects of Scapharca Subcrenata Extraction on cyclophosphamide in model mice. The models of mouse were induced with S180 tumor and cyclophosphamide. The tumor inhibiting rates,white blood cell number,giant cell phagocytosis,hemolysin level and indexes of thymus and spleen were determined to evaluate the synergism and attenuation effects of Scapharca Subcrenata Extraction on cyclophosphamide. Compared with cyclophosphamide group,the tumor inhibiting rates,white blood cell number,giant cell phagocytosis,hemolysin level and indexes of thymus and spleen were increased markedly in cyclophosphamide plus Scapharca Subcrenata Extraction groups. Scapharca Subcrenata Extraction has a remarkable synergism and attenuation effects on cyclophosphamide through its immune adjustment function.