神经阻滞联合丹皮酚磺酸钠治疗带状疱疹后神经痛的临床研究

Efficacy of nerve block combined with sodium paeonol sulfate in the treatment of postherpetic neuralgia

目的观察椎旁神经阻滞联合丹皮酚磺酸钠治疗带状疱疹后神经痛的疗效、方法和安全性。方法带状疱疹后神经痛患者50例,随机分为2组：Ⅰ组（n=25）：神经阻滞联合丹皮酚磺酸钠综合治疗;Ⅱ组（n=25）：单用神经阻滞治疗。以治疗前后VAS评分、伴随症状改善情况和合用止痛药物情况综合评价治疗效果。结果Ⅰ组、Ⅱ组治疗前的VAS评分分别为8.92±0.76、8.52±1.05,治疗后1~3周,VAS评分分别为3.24±0.78、2.64±0.49、1.28±0.79,5.08±0.64、4.12±0.78、3.12±0.67,VAS评分均明显降低,与治疗前比较差异有统计学意义（P〈0.05）,与Ⅱ组比较,Ⅰ组VAS评分下降程度更为明显（P〈0.05）,症状明显改善且未出现不良反应（P〈0.05）,合用止痛药物次数明显减少。结论椎旁神经阻滞联合丹皮酚磺酸钠综合治疗,对缓解带状疱疹后神经痛及改善神经症状,疗效显著而安全。

Objective To observe the efficacy and safety of paravertebral nerve block combined with sodium paeonol sulfate on the postherpetic neuralgia（ PHN）. Methods Fifty patients suffering from PHN were selected. The patients were randomly divided into two groups ： group Ⅰ（ n = 25） received nerve block combined with sodium paeonol sulfate,group Ⅱ（ n = 25） was given nerve block. The clinical efficacy was evaluated before and after treatment by visual analogue scale（ VAS）,improvement of simultaneous phenomenon and application of analgesic drug. Results VAS of groupⅠ and group Ⅱ were 8. 92 ± 0. 76 and 8. 52 ± 1. 05 respectively before treatment,the VAS at one week,two weeks,three weeks after treatment were 3. 24 ± 0. 78,2. 64 ± 0. 49,1. 28 ± 0. 79 and 5. 08 ± 0. 64,4. 12 ± 0. 78,3. 12 ± 0. 67 respectively. VAS significantly decreased after treatment（ P〈0. 05）,there were sighificant differences between the two groups（ P〈0. 05）,and symptoms of groupⅠ improved markedly without apparent adverse reactions（ P〈0. 05）,the number of times of analgesic drug use in groupⅠ significantly decreased compared with group Ⅱ. Conclusion The clinical effect of paravertebral nerve block combined with sodium paeonol sulfate is efficient on relief of PHN and symptoms of neuropathy with high safety.