围手术期质子泵抑制剂预防应激性溃疡用药分析

Analysis of proton pump inhibitors use in the perioperative period

目的调查我院外科围术期使用质子泵抑制剂预防应激性溃疡的情况,促进合理用药。方法抽取2013年8月至2014年1月我院外科病区使用质子泵抑制剂的患者360例,采用回顾性分析法对应激性溃疡风险进行评估。结果 53.06%的患者不存在应激性溃疡风险;质子泵抑制剂使用疗程≥6 d的患者占39.44%;无应激性溃疡风险因素与有应激性溃疡风险因素患者使用质子泵抑制剂的费用分别占药物总费用的8.04%和6.12%。结论外科在围术期使用质子泵抑制剂预防应激性溃疡时,存在不合理用药情况,还需加强管理,共同制定质子泵抑制剂的使用标准和规范,在实践中探索和积累更多的循证医学证据,防止质子泵抑制剂的过度使用。

Objective To investigate the situation of proton pump inhibitors use in perioperative patients,and enhance the level of rational drug use. Methods 360 cases used proton pump inhibitors were chose from August 2013 to January 2014 in surgical ward,and the risk factors of stress ulcer were analyzed retrospectively. Results 53. 06% of the patients had no risk of stress ulcer,39. 44% of the patients used proton pump inhibitors treatment for more than 6d. The cost of proton pump inhibitors in patients without stress ulcer risk factors and patients with stress ulcer risk factors counted for 8. 04% and 6. 12% respectively. Conclusion There is irrational drug use in perioperative use of proton pump inhibitors,therefore,more pow erful management on proton pump inhibitor is needed,the standards and norms of proton pump inhibitor should be developed,more EBM evidence should be explored and accumulated in practice,to prevent excessive use of proton pump inhibitor.