硫糖铝联用黄连素治疗慢性顽固性胃炎的临床疗效观察

To Observe the Clinical Curative Effect of Sucralfate Combined with Berberine in Treatment of Chronic Gastritis

目的分析探讨硫糖铝联用黄连素治疗慢性顽固性胃炎的临床疗效。方法选取我院近年来收治的120例慢性顽固性胃炎患者作为研究对象,按照数字抽签法将其随机分为研究组与对照组,每组60例,对照组给予常规治疗,研究组给予硫糖铝联合黄连素治疗,观察两组患者幽门螺旋杆菌转阴情况,总结临床治疗效果。结果研究组治愈率为43.3%,总有效率为93.3%,对照组治愈率为25.0%,总有效率为66.7%,研究组治疗效果明显优于对照组(P<0.05)。研究组患者Hp转阴率为73.3%,对照组Hp转移率为40.0%,研究组患者Hp转阴率明显高于对照组(P<0.05)。两组均未发生严重的不良反应。结论采用硫糖铝与黄连素治疗慢性顽固性胃炎具有显著的临床疗效,且无严重的不良反应,有效性与安全性均有保证,可推广应用。

Objective To analyze the clinical efficacy of sucralfatecombined with berberine in treatment of chronic gastritis. Methods 120 cases of chronic gastritis patients were chosen in our hospital in recent years as the research object, according to figures wererandomly divided into study group and control group, 60 cases in each group, the control group was given conventional treatment, the patients in study group received sucralfate combined with berberine treatment, two groups were observed in patients with Helicobacter pylori negative situation, to summarize the clinical treatment effect. Results In the study group, the cure rate was 43.3%, the total effective rate was 93.3%, control group, the cure rate was 25%, the total effective rate was 66.7%, the treatment group was better than the control group（P 0.05）. Research group of patients with Hp negative rate was 73.3%, the control transfer rate was 40% in group Hp, the patients in study group were Hp negative rate was significantly higher than the control group（P〈0.05）. The two groups were no serious adverse reactions. Conclusion The use of sucralfateand berberine in treatment of chronic gastritis has significant clinical efficacy, and no serious adverse reactions, effectiveness and safetycan be guaranteed, and can be popularized and applied.