非霍奇金淋巴瘤与乙型肝炎病毒感染的相关性

Correlation between non-Hodgkin lymphoma and hepatitis B virus infection

目的探讨非霍奇金淋巴瘤(NHL)与乙型肝炎病毒(HBV)感染的相关性。方法选取2008年1月至2013年12月间的108例NHL患者作为观察组,同期216例其他恶性肿瘤患者(原发性肝癌除外)作为对照组。比较两组患者的HBV感染率和乙肝表面抗原(HBs Ag)阳性率,分析不同NHL患者的临床资料与HBV感染的相关性。结果观察组患者的HBV感染率为38.9%(42/108),Hbs Ag阳性率为26.9%(29/108);对照组分别为21.3%(46/216)和15.3%(33/216),组间差异均有统计学意义(P<0.05)。HBV的感染率与患者的肿瘤类型和临床分期有明显相关性(P<0.05),与患者年龄和性别无明显相关性(P>0.05)。结论 NHL与HBV感染具有一定的相关性,临床上应给予一定的重视。

Objective To explore the correlation between non-Hodgkin lymphoma （NHL） and hepatitis B virus （HBV） infection. Methods A total of 108 patients with NHL during January 2008 to De- cember 2013 were chosen as observation group, and 216 patients of other cancer （except hepatoma） were chosen as control group. HBV infection rate and positive rate of hepatitis B surface antigen （HbsAg） of two groups were compared. Clinical data of NHL and HBV infection in two groups were analysed. Results In observation group, HBV infection rate was 38.9% （42/108）, positive rate of HbsAg was 26. 9% （29/108）. While in control group, HBV infection rate was 21.3% （46/216）, positive rate of HbsAg is 15.3% （33/216）, with statistical signigicance （P 〈 0. 05 ）. The type and stage of N HL had signigicant relevance with infection of HBV （P 〈 0. 05 ）. The age, and gender had no signigicant relevance with infec- tion of HBV （ P 〉 0. 05 ）. Conclusions NHL is relative to HBV infection, which should be given some at- tention for clinicians.