阿奇霉素与清开灵序贯疗法治疗小儿肺炎的随机对照研究

Randomized controlled studies on the effect of azithromycin and Qingkailing sequential therapy in the treatment of children with pneumonia

目的对比分析阿奇霉素与清开灵序贯疗法治疗小儿肺炎的临床效果及安全性。方法选取2012年2月至2014年9月我院收治的肺炎患儿162例,随机分为观察组(采用阿奇霉素序贯疗法治疗)和对照组(采用清开灵序贯疗法治疗),每组81例,比较两组有效率、临床症状消失时间、住院时间及不良反应发生情况。结果观察组与对照组比较有效率、胸部影像明显吸收比例均较高,临床症状消失时间及住院时间均较少,差异有统计学意义(P<0.05),两组不良反应总发生率比较差异无统计学意义(P>0.05)。结论肺炎患儿采用阿奇霉素序贯疗法治疗效果显著,优于清开灵序贯疗法治疗,有较高的安全性,可在临床推广应用。

Objective This article aimed to compare and analyze the effect and safety of azithromycin and Qingkailing sequential therapy in the treatment of children with pneumonia. Methods 162 cases of childrenpneumonia patients in our hospital during February 2012 and September 2014 were selected,they were randomly divided into the observation group（ used azithromycin sequential therapy） and control group（ used Qingkailing sequential therapy）, 81 cases of patients in each group. The efficient,time of clinical symptomsdisappearing,hospitalization time and adverse events of the two groups were compared. Results The efficient and chest imaging absorb proportion of the observation group were significantly higher than control group,the time of disappearance of clinical symptoms and hospital stay of observe group were less than that of control group,the differenceswerestatistically significant（ P〈0. 05）. The overall incidence of adverse reactions between the two groups was not significant difference（ P〉0. 05）. Conclusions Azithromycin sequential therapy in the treatment of children with pneumonia can obtain better efficacy than Qingkailing sequential therapy,so it can be applied in clinical practice.