妊娠高血压疾病患者血CysC、UA、BUN及Cr检测的临床应用

Analysis of test values of serum Cystatin C,UA,BUN and Cr in hypertensive disorder complicating pregnancy

目的探讨妊娠期高血压疾病患者血清胱抑素C(Cys C)、血尿酸(UA)、尿素氮(BUN)及肌酐(Cr)检测指标的临床应用价值及意义。方法用日立7180全自动生化分析仪对100例妊娠期高血压疾病患者及100例正常孕妇进行血清Cys C、UA、BUN、Cr的检测。结果重度及轻度子痫前期组Cys C值明显高于正常孕妇组,且有显著性差异(P<0.01);重度子痫前期组Cys C明显高于轻度子痫前期组,有显著性差异(P<0.05)。重度子痫前期组UA、BUN、Cr明显高于正常孕妇组,有显著性差异(P<0.01),但轻度子痫前期组UA、BUN、Cr与正常孕妇组相比,无显著性差异(P>0.05)。结论血Cys C的含量随着娠期高血压疾病的严重程度其含量明显升高。检测Cys C的同时,联合检测血UA、BUN、Cr对娠期高血压疾病并发的早期肾功能损害有着较好的临床诊断价值。

Objective：To detect the serum Cystatin C,uric acid（UA）,usea nitrogen（BUN）and creatinine（Cr）in pregnancy and investigate the correlation between the test values and hypertensive disorder complicating pregnancy. Methods：The serum Cystatin C,uric acid（UA）,usea nitrogen（BUN）and creatinine（Cr）of 100 cases of pregnant women with hypertensive disorder complicating pregnancy and 100 cases of normal women in mid trimester or late trimester pregnancy were testes with eos-bravo. Results：The test values of serum Cystatin C of pregnant women in severe pre-eclampsia and mild preeclampsia were higher obviously than the values of normal pregnant women. There was statistical significance of difference（P0.01）.The test values of serum Cystatin C of pregnant women in severe pre-eclampsia were higher than the test values in mild pre-eclampsia（P0.05）.The test values of uric acid（UA）,usea nitrogen（BUN）and creatinine（Cr）of pregnant women in severe pre-eclampsia were higher obviously than the values of normal pregnant women. There was statistical significance of difference（P0.01）. There was not statistical significance of difference（P0.05）between the test values of uric acid（UA）,usea nitrogen（BUN）and creatinine（Cr）of pregnant women in mild pre-eclampsia and the values of normal pregnant women. Conclusions：The levels of Cystatin C would be utilized to estimate the degree of renal impairment which was induced of hypertensive disorder complicating pregnancy. So the joint detection of the serum Cystatin C,uric acid（UA）,usea nitrogen（BUN）and creatinine（Cr）in pregnancy would be necessary for understanding the development of hypertensive disorder complicating pregnancy.