临沂地区816例高龄孕妇产前羊水细胞遗传学诊断

Prenatal cytogenetic diagnosis study of 816 cases of advanced pregnant women in Linyi area

目的通过高龄孕妇产前胎儿染色体核型结果分析,探讨高龄孕妇胎儿染色体异常的风险。方法通过对816例高龄孕妇行羊水细胞遗传学检查,探讨高龄孕妇胎儿染色体异常的比率,对比35~37岁、38~40岁、≥41岁三组孕妇胎儿染色体异常发生率,分析不同年龄组胎儿染色体异常的风险比率。结果 816例高龄孕妇中检测出胎儿染色体核型异常33例,异常发生率为4.04%,且随孕妇年龄增长,胎儿染色体异常的发生率增高。结论随着孕妇年龄增长,胎儿染色体异常几率增加,故高龄孕妇有必要行产前诊断。

Objective：To analyze the association between fetal chromosome abnormalities and advanced pregnant women duringpregnancy,thus to establish prenatal diagnostic standards and increase the detection rate of prenatal fetal chromosome abnormalities.Methods：Mid-trimester amniocentesis was drawn and fetal chromosomes were analyzed in 816 advanced maternal age women. Results：Among the 816 different prenatal diagnostic samples,there were 33 cases of abnormal karyotypes,and the rate of abnormalities was4.04%. Inadvanced pregnant women,the probability of chromosomal abnormalities was increased with their ageincreasing. Conclusions：Risk of fetal chromosome abnormalities is higher in advanced pregnant women,appropriate techniques should be used toscreenfetal chromosomes during different gestationweeksin advanced pregnant women.