高危型人乳头瘤病毒感染与宫颈癌前病变及宫颈癌的相关性分析

Correlation analysis between high-risk human papillomavirus infection and precancerous lesions of cervix uteri and cervical cancer

目的探讨高危型人乳头瘤病毒(HPV)感染与宫颈癌前病变以及宫颈癌的相关性。方法 120例宫颈癌或是癌前病变患者,其中60例为宫颈癌前病变患者(癌前病变组),60例为宫颈癌患者(宫颈癌组),将其归为观察组,同时期60例阴道炎宫颈无细胞学改变的患者设为对照组。采用宫颈液基细胞学检查法与宫颈刮片、免疫组化予以筛查分析,同时还采用达安PCR-反向点杂交法检测,对比分析各组检测结果。结果高危型HPV总阳性率为56.67%,癌前病变组、宫颈癌组以及对照组患者的高危型HPV阳性率分别为65%、95%、10%,三组患者的阳性率对比差异具有统计学意义(P<0.05)。结论高危型HPV感染与宫颈癌前病变以及宫颈癌具有非常密切的关系,而在高危型HPV感染中以HPV16感染为主。

Objective To investigate the correlation between high-risk human papillomavitus （HPV） infection, precancerous lesions of cervix uteri and cervical cancer. Methods Among 120 patients with cervical cancer or precancerous lesions, there were 60 cases with precancerous lesions of cervix uteri （precancerous lesions group） and 60 cases＇ with cervical cancer （cervical cancer group）. They were chosen as the observation group, and another 60 patients without cytological changes of cervix uteri in colpitis were taken as the control group. Cervix uteri thinprep cytology test, cervical scraping smear, and immunohistochemcial method were applied for screening and analysis, and Ann PCR-reverse dot blot method was used for detection. Examination results were compared between the groups. Results The total positive rate of high-risk HPV was 56.67%, and the positive rates of high-risk HPV in precancerous lesions group, cervical cancer group and control group were respectively 65%, 95%, and 10%. The difference of positive rate between the three groups had statistical significance （P〈0.05）. Conclusion High-risk HPV has close relationship with precancerous lesions of cervix uteri and cervical cancer, and the infection of high-risk HPV was mainly in HPV 16.